BTK T474M
Gene Variant Detail

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Gene BTK
Variant T474M
Impact List missense
Protein Effect no effect
Gene Variant Descriptions BTK T474M lies within the protein kinase domain of the Btk protein (UniProt.org). T474M demonstrates kinase activity similar to wild-type Btk as determined by in vitro autophosphorylation (PMID: 27571029, PMID: 28573668).
Associated Drug Resistance
Category Variants Paths

BTK mutant BTK T474M

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Transcript NM_000061.3
gDNA chrX:g.101356196_101356197delCTinsTG
cDNA c.1421_1422delCTinsTG
Protein p.T474M
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000061 chrX:g.101356196_101356197delAGinsCA c.1421_1422delCTinsTG p.T474M RefSeq GRCh38/hg38
NM_000061.2 chrX:g.101356196_101356197delCTinsTG c.1421_1422delCTinsTG p.T474M RefSeq GRCh38/hg38
NM_000061.3 chrX:g.101356196_101356197delCTinsTG c.1421_1422delCTinsTG p.T474M RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BTK T474M Advanced Solid Tumor predicted - resistant Ibrutinib Preclinical - Biochemical Actionable In a preclinical study, treatment with Imbruvica (ibrutinib) failed to inhibit Btk activity in cell lines expressing BTK T474M in culture (PMID: 33526860). 33526860
BTK T474M Advanced Solid Tumor predicted - resistant Acalabrutinib Preclinical - Biochemical Actionable In a preclinical study, treatment with Calquence (acalabrutinib) failed to inhibit Btk activity in a cell line expressing BTK T474M in culture (PMID: 33526860). 33526860