TP53 R158P
Gene Variant Detail

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Gene TP53
Variant R158P
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions TP53 R158P lies within the DNA-binding domain of the Tp53 protein (PMID: 22713868). R158P results in decreased Tp53 transactivation activity as demonstrated by loss of p21 expression and decreased activation of Tp53 targets in response to a DNA damaging agent, and also results in aberrant gene regulation in cultured cells (PMID: 31067569).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon5 TP53 R158P

TP53 mutant TP53 inact mut TP53 R158P

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Transcript NM_000546.6
gDNA chr17:g.7675139C>G
cDNA c.473G>C
Protein p.R158P
Source Database RefSeq
Genome Build GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.