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Gene APC
Variant P1420L
Impact List missense
Protein Effect unknown
Gene Variant Descriptions APC P1420L lies within the beta-catenin binding and downregulation region of the Apc protein (PMID: 14672538). P1420L has been identified in sequencing studies (PMID: 16906516, PMID: 27998968), but has not been biochemically characterized and therefore, its effect on Apc protein function is unknown (PubMed, Aug 2024).
Associated Drug Resistance
Category Variants Paths

APC mutant APC P1420L

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Transcript NM_000038.6
gDNA chr5:g.112839853C>T
cDNA c.4259C>T
Protein p.P1420L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000038 chr5:g.112839853C>T c.4259C>T p.P1420L RefSeq GRCh38/hg38
NM_001354895.1 chr5:g.112839853C>T c.4259C>T p.P1420L RefSeq GRCh38/hg38
NM_001127510 chr5:g.112839853C>T c.4259C>T p.P1420L RefSeq GRCh38/hg38
NM_001127510.3 chr5:g.112839853C>T c.4259C>T p.P1420L RefSeq GRCh38/hg38
NM_001407451.1 chr5:g.112839874C>T c.4259C>T p.P1420L RefSeq GRCh38/hg38
NM_000038.6 chr5:g.112839853C>T c.4259C>T p.P1420L RefSeq GRCh38/hg38
NM_001407450.1 chr5:g.112839853C>T c.4259C>T p.P1420L RefSeq GRCh38/hg38
NM_001354895.2 chr5:g.112839853C>T c.4259C>T p.P1420L RefSeq GRCh38/hg38
NM_001127510.2 chr5:g.112839853C>T c.4259C>T p.P1420L RefSeq GRCh38/hg38
NM_000038.5 chr5:g.112839853C>T c.4259C>T p.P1420L RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries