DNMT3A P59L
Gene Variant Detail

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Gene DNMT3A
Variant P59L
Impact List missense
Protein Effect unknown
Gene Variant Descriptions DNMT3A P59L does not lie within any known functional domains of the Dnmt3a protein (UniProt.org). P59L has been identified in the scientific literature (PMID: 27900369), but has not been biochemically characterized and therefore, its effect on Dnmt3a protein function is unknown (PubMed, Oct 2025).
Associated Drug Resistance
Category Variants Paths

DNMT3A mutant DNMT3A P59L

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Transcript NM_022552.5
gDNA chr2:g.25300140G>A
cDNA c.176C>T
Protein p.P59L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_175630.1 chr2:g.25300140G>A c.176C>T p.P59L RefSeq GRCh38/hg38
NM_175629.2 chr2:g.25300140G>A c.176C>T p.P59L RefSeq GRCh38/hg38
XM_011532664 chr2:g.25300140G>A c.176C>T p.P59L RefSeq GRCh38/hg38
XM_017003526.1 chr2:g.25300140G>A c.176C>T p.P59L RefSeq GRCh38/hg38
XM_017003527 chr2:g.25248047G>A c.176C>T p.P59L RefSeq GRCh38/hg38
XM_047443598.1 chr2:g.25248047G>A c.176C>T p.P59L RefSeq GRCh38/hg38
NM_175629.2 chr2:g.25300140G>A c.176C>T p.P59L RefSeq GRCh38/hg38
XM_011532664.3 chr2:g.25300140G>A c.176C>T p.P59L RefSeq GRCh38/hg38
XM_017003526 chr2:g.25300140G>A c.176C>T p.P59L RefSeq GRCh38/hg38
XM_047443593.1 chr2:g.25300140G>A c.176C>T p.P59L RefSeq GRCh38/hg38
XM_011532664.2 chr2:g.25300140G>A c.176C>T p.P59L RefSeq GRCh38/hg38
NM_022552 chr2:g.25300140G>A c.176C>T p.P59L RefSeq GRCh38/hg38
XM_011532667.3 chr2:g.25248047G>A c.176C>T p.P59L RefSeq GRCh38/hg38
NM_022552.5 chr2:g.25300140G>A c.176C>T p.P59L RefSeq GRCh38/hg38
XM_047443599.1 chr2:g.25248047G>A c.176C>T p.P59L RefSeq GRCh38/hg38
NM_175629 chr2:g.25300140G>A c.176C>T p.P59L RefSeq GRCh38/hg38
XM_005264175 chr2:g.25300140G>A c.176C>T p.P59L RefSeq GRCh38/hg38
XM_005264177 chr2:g.25248047G>A c.176C>T p.P59L RefSeq GRCh38/hg38
XM_017003526.2 chr2:g.25300140G>A c.176C>T p.P59L RefSeq GRCh38/hg38
NM_175630 chr2:g.25300140G>A c.176C>T p.P59L RefSeq GRCh38/hg38
XM_047443597.1 chr2:g.25248047G>A c.176C>T p.P59L RefSeq GRCh38/hg38
NM_022552.4 chr2:g.25300140G>A c.176C>T p.P59L RefSeq GRCh38/hg38
XM_011532667 chr2:g.25248047G>A c.176C>T p.P59L RefSeq GRCh38/hg38
NM_001320892 chr2:g.25300140G>A c.176C>T p.P59L RefSeq GRCh38/hg38
XM_005264175.5 chr2:g.25300140G>A c.176C>T p.P59L RefSeq GRCh38/hg38
NM_175630.1 chr2:g.25300140G>A c.176C>T p.P59L RefSeq GRCh38/hg38
XM_047443596.1 chr2:g.25248047G>A c.176C>T p.P59L RefSeq GRCh38/hg38
XM_005264175.6 chr2:g.25300140G>A c.176C>T p.P59L RefSeq GRCh38/hg38
XM_011532667.4 chr2:g.25248047G>A c.176C>T p.P59L RefSeq GRCh38/hg38
NM_001375819.1 chr2:g.25248047G>A c.176C>T p.P59L RefSeq GRCh38/hg38
XM_005264177.4 chr2:g.25248047G>A c.176C>T p.P59L RefSeq GRCh38/hg38
NM_001320892.1 chr2:g.25300140G>A c.176C>T p.P59L RefSeq GRCh38/hg38
XM_017003527.1 chr2:g.25248047G>A c.176C>T p.P59L RefSeq GRCh38/hg38
XM_017003527.2 chr2:g.25248047G>A c.176C>T p.P59L RefSeq GRCh38/hg38
NM_001320892.2 chr2:g.25300140G>A c.176C>T p.P59L RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References