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Gene TP53
Variant Y205C
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions TP53 Y205C lies within the DNA binding domain of the Tp53 protein (UniProt.org). Y205C demonstrates increased proliferation, migration, invasion, and protein stability in culture (PMID: 37030635) and decreased Tp53 transactivation activity in cultured cells (PMID: 15037740, PMID: 22710932).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon6 TP53 Y205C

TP53 mutant TP53 inact mut TP53 Y205C

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Transcript NM_000546.6
gDNA chr17:g.7674917T>C
cDNA c.614A>G
Protein p.Y205C
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001126113.2 chr17:g.7674917T>C c.614A>G p.Y205C RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7674917T>C c.614A>G p.Y205C RefSeq GRCh38/hg38
NM_001126113 chr17:g.7674917T>C c.614A>G p.Y205C RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7674917T>C c.614A>G p.Y205C RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7674917T>C c.614A>G p.Y205C RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7674917T>C c.614A>G p.Y205C RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7674917T>C c.614A>G p.Y205C RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7674917T>C c.614A>G p.Y205C RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7674917T>C c.614A>G p.Y205C RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7674917T>C c.614A>G p.Y205C RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7674917T>C c.614A>G p.Y205C RefSeq GRCh38/hg38
NM_000546 chr17:g.7674917T>C c.614A>G p.Y205C RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7674917T>C c.614A>G p.Y205C RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7674917T>C c.614A>G p.Y205C RefSeq GRCh38/hg38
NM_001126112 chr17:g.7674917T>C c.614A>G p.Y205C RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7674917T>C c.614A>G p.Y205C RefSeq GRCh38/hg38
NM_001126114 chr17:g.7674917T>C c.614A>G p.Y205C RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
TP53 Y205C loss of function p53 Activator p53 Gene Therapy