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Gene STK11
Variant E57fs
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions STK11 E57fs results in a change in the amino acid sequence of the Stk11 protein beginning at aa 57 of 433, likely resulting in premature truncation of the functional protein (UniProt.org). E57fs has not been characterized however, due to the effects of other truncation mutations downstream of E57 (PMID: 23612973), is predicted to lead to a loss of Stk11 protein function.
Associated Drug Resistance
Category Variants Paths

STK11 mutant STK11 inact mut STK11 E57fs

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Transcript NM_000455.5
gDNA chr19:g.(1207081_1207082)
cDNA c.(169_168)
Protein p.E57fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000455.4 chr19:g.(1207081_1207082) c.(169_168) p.E57fs RefSeq GRCh38/hg38
XM_005259617 chr19:g.(1207081_1207082) c.(169_168) p.E57fs RefSeq GRCh38/hg38
NM_000455.5 chr19:g.(1207081_1207082) c.(169_168) p.E57fs RefSeq GRCh38/hg38
XM_005259618.3 chr19:g.(1207081_1207082) c.(169_168) p.E57fs RefSeq GRCh38/hg38
NM_001407255.1 chr19:g.(1207081_1207082) c.(169_168) p.E57fs RefSeq GRCh38/hg38
XM_005259618 chr19:g.(1207081_1207082) c.(169_168) p.E57fs RefSeq GRCh38/hg38
NM_000455 chr19:g.(1207081_1207082) c.(169_168) p.E57fs RefSeq GRCh38/hg38
XM_005259617.3 chr19:g.(1207081_1207082) c.(169_168) p.E57fs RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
STK11 E57fs lung non-small cell carcinoma sensitive Trametinib Preclinical - Cell culture Actionable In a preclinical study, non-small cell lung cancer cell lines harboring STK11 inactivating mutations, such as STK11 E57fs, demonstrated increased sensitivity to Mekinist (trametinib) in culture (PMID: 27821489). 27821489