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Gene TP53
Variant P190S
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions TP53 P190S lies within the DNA binding domain of the Tp53 protein (UniProt.org). P190S confers a loss of function to the Tp53 protein, as demonstrated by decreased suppression of Vimentin mRNA expression, decreased ability to suppress cell viability, increased cell migration, and increased cell invasion in cell culture (PMID: 28408749).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon6 TP53 P190S

TP53 mutant TP53 inact mut TP53 P190S

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Transcript NM_000546.6
gDNA chr17:g.7674963G>A
cDNA c.568C>T
Protein p.P190S
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001407268.1 chr17:g.7674963G>A c.568C>T p.P190S RefSeq GRCh38/hg38
NM_001126117.2 chr17:g.7673564G>A c.568C>T p.P190S RefSeq GRCh38/hg38
NM_001126115.1 chr17:g.7673564G>A c.568C>T p.P190S RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7674963G>A c.568C>T p.P190S RefSeq GRCh38/hg38
NM_000546 chr17:g.7674963G>A c.568C>T p.P190S RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7674963G>A c.568C>T p.P190S RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7674963G>A c.568C>T p.P190S RefSeq GRCh38/hg38
NM_001126113 chr17:g.7674963G>A c.568C>T p.P190S RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7674963G>A c.568C>T p.P190S RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7674963G>A c.568C>T p.P190S RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7674963G>A c.568C>T p.P190S RefSeq GRCh38/hg38
NM_001126117 chr17:g.7673564G>A c.568C>T p.P190S RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7674963G>A c.568C>T p.P190S RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7674963G>A c.568C>T p.P190S RefSeq GRCh38/hg38
NM_001126116.1 chr17:g.7673564G>A c.568C>T p.P190S RefSeq GRCh38/hg38
NM_001126116.2 chr17:g.7673564G>A c.568C>T p.P190S RefSeq GRCh38/hg38
NM_001126115 chr17:g.7673564G>A c.568C>T p.P190S RefSeq GRCh38/hg38
NM_001126112 chr17:g.7674963G>A c.568C>T p.P190S RefSeq GRCh38/hg38
NM_001126117.1 chr17:g.7673564G>A c.568C>T p.P190S RefSeq GRCh38/hg38
NM_001126115.2 chr17:g.7673564G>A c.568C>T p.P190S RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7674963G>A c.568C>T p.P190S RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7674963G>A c.568C>T p.P190S RefSeq GRCh38/hg38
NM_001126114 chr17:g.7674963G>A c.568C>T p.P190S RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7674963G>A c.568C>T p.P190S RefSeq GRCh38/hg38
NM_001126116 chr17:g.7673564G>A c.568C>T p.P190S RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7674963G>A c.568C>T p.P190S RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
TP53 P190S loss of function p53 Activator p53 Gene Therapy