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Gene | TP53 |
Variant | P190S |
Impact List | missense |
Protein Effect | loss of function |
Gene Variant Descriptions | TP53 P190S lies within the DNA binding domain of the Tp53 protein (UniProt.org). P190S confers a loss of function to the Tp53 protein, as demonstrated by decreased suppression of Vimentin mRNA expression, decreased ability to suppress cell viability, increased cell migration, and increased cell invasion in cell culture (PMID: 28408749). |
Associated Drug Resistance | |
Category Variants Paths |
TP53 mutant TP53 exon6 TP53 P190S TP53 mutant TP53 inact mut TP53 P190S |
Transcript | NM_000546.6 |
gDNA | chr17:g.7674963G>A |
cDNA | c.568C>T |
Protein | p.P190S |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_001126112 | chr17:g.7674963G>A | c.568C>T | p.P190S | RefSeq | GRCh38/hg38 |
NM_001126114 | chr17:g.7674963G>A | c.568C>T | p.P190S | RefSeq | GRCh38/hg38 |
NM_001126117 | chr17:g.7673564G>A | c.568C>T | p.P190S | RefSeq | GRCh38/hg38 |
NM_001126116 | chr17:g.7673564G>A | c.568C>T | p.P190S | RefSeq | GRCh38/hg38 |
NM_001126112.2 | chr17:g.7674963G>A | c.568C>T | p.P190S | RefSeq | GRCh38/hg38 |
NM_001126113.3 | chr17:g.7674963G>A | c.568C>T | p.P190S | RefSeq | GRCh38/hg38 |
NM_001126115.2 | chr17:g.7673564G>A | c.568C>T | p.P190S | RefSeq | GRCh38/hg38 |
NM_001126117.1 | chr17:g.7673564G>A | c.568C>T | p.P190S | RefSeq | GRCh38/hg38 |
NM_001407268.1 | chr17:g.7674963G>A | c.568C>T | p.P190S | RefSeq | GRCh38/hg38 |
NM_001126112.3 | chr17:g.7674963G>A | c.568C>T | p.P190S | RefSeq | GRCh38/hg38 |
NM_000546.6 | chr17:g.7674963G>A | c.568C>T | p.P190S | RefSeq | GRCh38/hg38 |
NM_001126114.2 | chr17:g.7674963G>A | c.568C>T | p.P190S | RefSeq | GRCh38/hg38 |
NM_001126116.1 | chr17:g.7673564G>A | c.568C>T | p.P190S | RefSeq | GRCh38/hg38 |
NM_001407266.1 | chr17:g.7674963G>A | c.568C>T | p.P190S | RefSeq | GRCh38/hg38 |
NM_001126113.2 | chr17:g.7674963G>A | c.568C>T | p.P190S | RefSeq | GRCh38/hg38 |
NM_001407264.1 | chr17:g.7674963G>A | c.568C>T | p.P190S | RefSeq | GRCh38/hg38 |
NM_001407270.1 | chr17:g.7674963G>A | c.568C>T | p.P190S | RefSeq | GRCh38/hg38 |
NM_001126113 | chr17:g.7674963G>A | c.568C>T | p.P190S | RefSeq | GRCh38/hg38 |
NM_001407262.1 | chr17:g.7674963G>A | c.568C>T | p.P190S | RefSeq | GRCh38/hg38 |
NM_001126117.2 | chr17:g.7673564G>A | c.568C>T | p.P190S | RefSeq | GRCh38/hg38 |
NM_001126116.2 | chr17:g.7673564G>A | c.568C>T | p.P190S | RefSeq | GRCh38/hg38 |
NM_000546 | chr17:g.7674963G>A | c.568C>T | p.P190S | RefSeq | GRCh38/hg38 |
NM_001126115 | chr17:g.7673564G>A | c.568C>T | p.P190S | RefSeq | GRCh38/hg38 |
NM_001126115.1 | chr17:g.7673564G>A | c.568C>T | p.P190S | RefSeq | GRCh38/hg38 |
NM_001126114.3 | chr17:g.7674963G>A | c.568C>T | p.P190S | RefSeq | GRCh38/hg38 |
NM_000546.5 | chr17:g.7674963G>A | c.568C>T | p.P190S | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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