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Gene TP53
Variant R273W
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions TP53 R273W is a hotspot mutation that lies within the DNA-binding domain of the Tp53 protein (PMID: 22713868). R273W is predicted to confer a loss of function to the Tp53 protein, as demonstrated by decreased gene transcription in response to Tgf-beta treatment in cell culture (PMID: 17875924).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon8 TP53 R273X TP53 R273W

TP53 mutant TP53 inact mut TP53 R273W

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Transcript NM_000546.6
gDNA chr17:g.7673801_7673803delCGTinsTGG
cDNA c.817_819delCGTinsTGG
Protein p.R273W
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001126112.2 chr17:g.7673801_7673803delCGTinsTGG c.817_819delCGTinsTGG p.R273W RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7673801_7673803delCGTinsTGG c.817_819delCGTinsTGG p.R273W RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7673801_7673803delCGTinsTGG c.817_819delCGTinsTGG p.R273W RefSeq GRCh38/hg38
NM_001126112 chr17:g.7673801_7673803delACGinsCCA c.817_819delCGTinsTGG p.R273W RefSeq GRCh38/hg38
NM_001126114 chr17:g.7673801_7673803delACGinsCCA c.817_819delCGTinsTGG p.R273W RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7673801_7673803delCGTinsTGG c.817_819delCGTinsTGG p.R273W RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7673801_7673803delCGTinsTGG c.817_819delCGTinsTGG p.R273W RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7673801_7673803delCGTinsTGG c.817_819delCGTinsTGG p.R273W RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7673801_7673803delCGTinsTGG c.817_819delCGTinsTGG p.R273W RefSeq GRCh38/hg38
NM_000546 chr17:g.7673801_7673803delACGinsCCA c.817_819delCGTinsTGG p.R273W RefSeq GRCh38/hg38
NM_001126113 chr17:g.7673801_7673803delACGinsCCA c.817_819delCGTinsTGG p.R273W RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7673801_7673803delCGTinsTGG c.817_819delCGTinsTGG p.R273W RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7673801_7673803delCGTinsTGG c.817_819delCGTinsTGG p.R273W RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7673801_7673803delCGTinsTGG c.817_819delCGTinsTGG p.R273W RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7673801_7673803delCGTinsTGG c.817_819delCGTinsTGG p.R273W RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7673801_7673803delCGTinsTGG c.817_819delCGTinsTGG p.R273W RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7673801_7673803delCGTinsTGG c.817_819delCGTinsTGG p.R273W RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries