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TP53 R273W - Gene Variant Detail

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Gene TP53
Variant R273W
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions TP53 R273W is a hotspot mutation that lies within the DNA-binding domain of the Tp53 protein (PMID: 22713868). R273W is predicted to confer a loss of function to the Tp53 protein, as demonstrated by decreased gene transcription in response to Tgf-beta treatment in cell culture (PMID: 17875924).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon8 TP53 R273X TP53 R273W

TP53 mutant TP53 inact mut TP53 R273W

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Transcript NM_000546.6
gDNA chr17:g.7673801_7673803delCGTinsTGG
cDNA c.817_819delCGTinsTGG
Protein p.R273W
Source Database RefSeq
Genome Build GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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