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Gene APC
Variant T1496fs
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions APC T1496fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1496 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). T1496fs has not been characterized, however, due to the effects of other truncation mutations downstream of T1496 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
Associated Drug Resistance
Category Variants Paths

APC mutant APC inact mut APC T1496fs

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Transcript NM_000038.6
gDNA chr5:g.(112840079_112840080)
cDNA c.(4486_4485)
Protein p.T1496fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001354900.1 chr5:g.(112840202_112840203) c.(4486_4485) p.T1496fs RefSeq GRCh38/hg38
NM_001407458.1 chr5:g.(112840382_112840383) c.(4486_4485) p.T1496fs RefSeq GRCh38/hg38
NM_000038 chr5:g.(112840079_112840080) c.(4486_4485) p.T1496fs RefSeq GRCh38/hg38
NM_001127510 chr5:g.(112840079_112840080) c.(4486_4485) p.T1496fs RefSeq GRCh38/hg38
NM_001354903.1 chr5:g.(112840382_112840383) c.(4486_4485) p.T1496fs RefSeq GRCh38/hg38
NM_001127510.3 chr5:g.(112840079_112840080) c.(4486_4485) p.T1496fs RefSeq GRCh38/hg38
NM_001407459.1 chr5:g.(112840382_112840383) c.(4486_4485) p.T1496fs RefSeq GRCh38/hg38
NM_000038.6 chr5:g.(112840079_112840080) c.(4486_4485) p.T1496fs RefSeq GRCh38/hg38
NM_001407450.1 chr5:g.(112840079_112840080) c.(4486_4485) p.T1496fs RefSeq GRCh38/hg38
NM_001354900.2 chr5:g.(112840202_112840203) c.(4486_4485) p.T1496fs RefSeq GRCh38/hg38
NM_000038.5 chr5:g.(112840079_112840080) c.(4486_4485) p.T1496fs RefSeq GRCh38/hg38
NM_001354895.1 chr5:g.(112840079_112840080) c.(4486_4485) p.T1496fs RefSeq GRCh38/hg38
NM_001354895.2 chr5:g.(112840079_112840080) c.(4486_4485) p.T1496fs RefSeq GRCh38/hg38
NM_001407460.1 chr5:g.(112840382_112840383) c.(4486_4485) p.T1496fs RefSeq GRCh38/hg38
NM_001354903.2 chr5:g.(112840382_112840383) c.(4486_4485) p.T1496fs RefSeq GRCh38/hg38
NM_001127510.2 chr5:g.(112840079_112840080) c.(4486_4485) p.T1496fs RefSeq GRCh38/hg38

Filtering

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References