Gene Variant Detail

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Gene TP53
Variant L111fs
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions TP53 L111fs results in a change in the amino acid sequence of the Tp53 protein beginning at aa 111 of 393, likely resulting in premature truncation of the functional protein (UniProt.org). L111fs has not been biochemically characterized however, due to the effects of truncation mutations downstream of L111 (PMID: 31081129, PMID: 34045312), is predicted to lead to a loss of Tp53 protein function.
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon4 TP53 L111fs

TP53 mutant TP53 inact mut TP53 L111fs

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Transcript NM_000546.6
gDNA chr17:g.(7676038_7676039)
cDNA c.(331_330)
Protein p.L111fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001126113 chr17:g.(7676038_7676039) c.(331_330) p.L111fs RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.(7676038_7676039) c.(331_330) p.L111fs RefSeq GRCh38/hg38
NM_000546 chr17:g.(7676038_7676039) c.(331_330) p.L111fs RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.(7676038_7676039) c.(331_330) p.L111fs RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.(7676038_7676039) c.(331_330) p.L111fs RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.(7676038_7676039) c.(331_330) p.L111fs RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.(7676038_7676039) c.(331_330) p.L111fs RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.(7676038_7676039) c.(331_330) p.L111fs RefSeq GRCh38/hg38
NM_000546.5 chr17:g.(7676038_7676039) c.(331_330) p.L111fs RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.(7676038_7676039) c.(331_330) p.L111fs RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.(7676038_7676039) c.(331_330) p.L111fs RefSeq GRCh38/hg38
NM_001126114 chr17:g.(7676038_7676039) c.(331_330) p.L111fs RefSeq GRCh38/hg38
NM_001126112 chr17:g.(7676038_7676039) c.(331_330) p.L111fs RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.(7676038_7676039) c.(331_330) p.L111fs RefSeq GRCh38/hg38
NM_000546.6 chr17:g.(7676038_7676039) c.(331_330) p.L111fs RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.(7676038_7676039) c.(331_330) p.L111fs RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.(7676038_7676039) c.(331_330) p.L111fs RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Protein Effect Treatment Approaches
TP53 L111fs loss of function - predicted p53 Gene Therapy