Gene Variant Detail

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Gene PIK3CA
Variant K944N
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions PIK3CA K944N lies within the PI3K/PI4K domain of the Pik3ca protein (UniProt.org). K944N results in activation of Pik3ca signaling as indicated by increased phosphorylation of Akt and Mapk3/Mapk1 (Erk1/2), and confers resistance to some EGFR inhibitors in cell culture (PMID: 28424201) and therefore, is predicted to lead to a gain of Pik3ca protein function.
Associated Drug Resistance Y
Category Variants Paths

PIK3CA mutant PIK3CA act mut PIK3CA K944N

PIK3CA mutant PIK3CA exon20 PIK3CA K944N

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Transcript NM_006218.4
gDNA chr3:g.179230272A>C
cDNA c.2832A>C
Protein p.K944N
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011512894 chr3:g.179230272A>C c.2832A>C p.K944N RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179230272A>C c.2832A>C p.K944N RefSeq GRCh38/hg38
XM_011512894.2 chr3:g.179230272A>C c.2832A>C p.K944N RefSeq GRCh38/hg38
NM_006218.4 chr3:g.179230272A>C c.2832A>C p.K944N RefSeq GRCh38/hg38
XM_006713658 chr3:g.179230272A>C c.2832A>C p.K944N RefSeq GRCh38/hg38
NM_006218 chr3:g.179230272A>C c.2832A>C p.K944N RefSeq GRCh38/hg38
XM_006713658.4 chr3:g.179230272A>C c.2832A>C p.K944N RefSeq GRCh38/hg38
NM_006218.3 chr3:g.179230272A>C c.2832A>C p.K944N RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries