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Gene PIK3CA
Variant V955I
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions PIK3CA V955I lies within the PI3K/PI4K domain of the Pik3ca protein (UniProt.org). V955I results in activation of Pik3ca signaling as indicated by increased phosphorylation of Akt and Mapk3/Mapk1 (Erk1/2), and confers resistance to Erbitux (cetuximab) in culture (PMID: 28424201), and therefore, is predicted to lead to a gain of Pik3ca protein function.
Associated Drug Resistance Y
Category Variants Paths

PIK3CA mutant PIK3CA act mut PIK3CA V955I

PIK3CA mutant PIK3CA exon20 PIK3CA V955I

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Transcript NM_006218.4
gDNA chr3:g.179230303G>A
cDNA c.2863G>A
Protein p.V955I
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006713658.4 chr3:g.179230303G>A c.2863G>A p.V955I RefSeq GRCh38/hg38
NM_006218.3 chr3:g.179230303G>A c.2863G>A p.V955I RefSeq GRCh38/hg38
NM_006218.4 chr3:g.179230303G>A c.2863G>A p.V955I RefSeq GRCh38/hg38
XM_011512894 chr3:g.179230303G>A c.2863G>A p.V955I RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179230303G>A c.2863G>A p.V955I RefSeq GRCh38/hg38
XM_011512894.2 chr3:g.179230303G>A c.2863G>A p.V955I RefSeq GRCh38/hg38
NM_006218 chr3:g.179230303G>A c.2863G>A p.V955I RefSeq GRCh38/hg38
XM_006713658 chr3:g.179230303G>A c.2863G>A p.V955I RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
PIK3CA V955I colorectal cancer resistant Cetuximab + Fluorouracil Case Reports/Case Series Actionable In a clinical study, PIK3CA V955I was identified as a potential mechanism for acquired Erbitux (cetuximab) resistance in a colorectal cancer patient, which is supported by cell culture studies demonstrating resistance to Erbitux (cetuximab) and Fluorouracil combination treatment in colorectal cancer cells over expressing PIK3CA V955I (PMID: 28424201). 28424201