Gene Variant Detail

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Gene TP53
Variant I255del
Impact List deletion
Protein Effect loss of function
Gene Variant Descriptions TP53 I255del results in the deletion of one amino acid in the DNA-binding domain of the Tp53 protein at amino acid 255 (PMID: 15510160). I255del results in decreased Tp53 transcriptional activity in a reporter assay and reduced growth suppression in cell culture (PMID: 30886117).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon7 TP53 I255del

TP53 mutant TP53 inact mut TP53 I255del

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Transcript NM_000546.6
gDNA chr17:g.7674202_7674204delATG
cDNA c.764_766delTCA
Protein p.I255delI
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001126113.2 chr17:g.7674202_7674204delATG c.764_766delTCA p.I255delI RefSeq GRCh38/hg38
NM_001276696.3 chr17:g.7673739_7673741delTCC c.763_765delGAG p.E255delE RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7674202_7674204delATG c.764_766delTCA p.I255delI RefSeq GRCh38/hg38
NM_001126118.1 chr17:g.7673739_7673741delTCC c.763_765delGAG p.E255delE RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7674202_7674204delATG c.764_766delTCA p.I255delI RefSeq GRCh38/hg38
NM_001407267.1 chr17:g.7673739_7673741delTCC c.763_765delGAG p.E255delE RefSeq GRCh38/hg38
NM_001126113 chr17:g.7674202_7674204delATG c.764_766delTCA p.I255delI RefSeq GRCh38/hg38
NM_001276695 chr17:g.7673739_7673741delTCC c.763_765delGAG p.E255delE RefSeq GRCh38/hg38
NM_001407269.1 chr17:g.7673739_7673741delTCC c.763_765delGAG p.E255delE RefSeq GRCh38/hg38
NM_001126118 chr17:g.7673739_7673741delTCC c.763_765delGAG p.E255delE RefSeq GRCh38/hg38
NM_001407271.1 chr17:g.7673739_7673741delTCC c.763_765delGAG p.E255delE RefSeq GRCh38/hg38
NM_001276696.1 chr17:g.7673739_7673741delTCC c.763_765delGAG p.E255delE RefSeq GRCh38/hg38
NM_001407263.1 chr17:g.7673739_7673741delTCC c.763_765delGAG p.E255delE RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7674202_7674204delATG c.764_766delTCA p.I255delI RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7674202_7674204delATG c.764_766delTCA p.I255delI RefSeq GRCh38/hg38
NM_001126118.2 chr17:g.7673739_7673741delTCC c.763_765delGAG p.E255delE RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7674202_7674204delATG c.764_766delTCA p.I255delI RefSeq GRCh38/hg38
NM_001126115.2 chr17:g.7669630_7669632delTGT c.763_765delACA p.T255delT RefSeq GRCh38/hg38
NM_001126115 chr17:g.7669630_7669632delTGT c.763_765delACA p.T255delT RefSeq GRCh38/hg38
NM_001276695.1 chr17:g.7673739_7673741delTCC c.763_765delGAG p.E255delE RefSeq GRCh38/hg38
NM_001276761.3 chr17:g.7673739_7673741delTCC c.763_765delGAG p.E255delE RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7674202_7674204delATG c.764_766delTCA p.I255delI RefSeq GRCh38/hg38
NM_000546 chr17:g.7674202_7674204delATG c.764_766delTCA p.I255delI RefSeq GRCh38/hg38
NM_001276696 chr17:g.7673739_7673741delTCC c.763_765delGAG p.E255delE RefSeq GRCh38/hg38
NM_001276760.3 chr17:g.7673739_7673741delTCC c.763_765delGAG p.E255delE RefSeq GRCh38/hg38
NM_001126115.1 chr17:g.7669630_7669632delTGT c.763_765delACA p.T255delT RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7674202_7674204delATG c.764_766delTCA p.I255delI RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7674202_7674204delATG c.764_766delTCA p.I255delI RefSeq GRCh38/hg38
NM_001276695.3 chr17:g.7673739_7673741delTCC c.763_765delGAG p.E255delE RefSeq GRCh38/hg38
NM_001126114 chr17:g.7674202_7674204delATG c.764_766delTCA p.I255delI RefSeq GRCh38/hg38
NM_001276761 chr17:g.7673739_7673741delTCC c.763_765delGAG p.E255delE RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7674202_7674204delATG c.764_766delTCA p.I255delI RefSeq GRCh38/hg38
NM_001276761.1 chr17:g.7673739_7673741delTCC c.763_765delGAG p.E255delE RefSeq GRCh38/hg38
NM_001407265.1 chr17:g.7673739_7673741delTCC c.763_765delGAG p.E255delE RefSeq GRCh38/hg38
NM_001276760.1 chr17:g.7673739_7673741delTCC c.763_765delGAG p.E255delE RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7674202_7674204delATG c.764_766delTCA p.I255delI RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7674202_7674204delATG c.764_766delTCA p.I255delI RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7674202_7674204delATG c.764_766delTCA p.I255delI RefSeq GRCh38/hg38
NM_001126112 chr17:g.7674202_7674204delATG c.764_766delTCA p.I255delI RefSeq GRCh38/hg38
NM_001276760 chr17:g.7673739_7673741delTCC c.763_765delGAG p.E255delE RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References