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Gene APC
Variant R805*
Impact List nonsense
Protein Effect loss of function - predicted
Gene Variant Descriptions APC R805* results in a premature truncation of the Apc protein at amino acid 805 of 2843 (UniProt.org). R805* is transforming in cell culture (PMID: 28769798), and due to the effects of other truncation mutations downstream of R805 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
Associated Drug Resistance
Category Variants Paths

APC mutant APC inact mut APC R805*

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Transcript NM_000038.6
gDNA chr5:g.112838007C>T
cDNA c.2413C>T
Protein p.R805*
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001127510.2 chr5:g.112838007C>T c.2413C>T p.R805* RefSeq GRCh38/hg38
NM_001354895.2 chr5:g.112838007C>T c.2413C>T p.R805* RefSeq GRCh38/hg38
NM_000038 chr5:g.112838007C>T c.2413C>T p.R805* RefSeq GRCh38/hg38
NM_001127510.3 chr5:g.112838007C>T c.2413C>T p.R805* RefSeq GRCh38/hg38
NM_001127510 chr5:g.112838007C>T c.2413C>T p.R805* RefSeq GRCh38/hg38
NM_001354895.1 chr5:g.112838007C>T c.2413C>T p.R805* RefSeq GRCh38/hg38
NM_000038.5 chr5:g.112838007C>T c.2413C>T p.R805* RefSeq GRCh38/hg38
NM_000038.6 chr5:g.112838007C>T c.2413C>T p.R805* RefSeq GRCh38/hg38
NM_001407450.1 chr5:g.112838007C>T c.2413C>T p.R805* RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
APC R805* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC S299Tfs*7 APC R805*