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Gene APC
Variant S1411fs
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions APC S1411fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1411 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). S1411fs has not been characterized, however, due to the effects of truncation mutations downstream of S1411 (PMID: 10346819, PMID: 18199528), is predicted to lead to a loss in Apc protein function.
Associated Drug Resistance
Category Variants Paths

APC mutant APC inact mut APC S1411fs

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Transcript NM_000038.6
gDNA chr5:g.(112839824_112839825)
cDNA c.(4231_4230)
Protein p.S1411fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000038.5 chr5:g.(112839824_112839825) c.(4231_4230) p.S1411fs RefSeq GRCh38/hg38
NM_001407452.1 chr5:g.(112839854_112839855) c.(4231_4230) p.S1411fs RefSeq GRCh38/hg38
NM_001354895.1 chr5:g.(112839824_112839825) c.(4231_4230) p.S1411fs RefSeq GRCh38/hg38
NM_001354898.1 chr5:g.(112839899_112839900) c.(4231_4230) p.S1411fs RefSeq GRCh38/hg38
NM_001127510.3 chr5:g.(112839824_112839825) c.(4231_4230) p.S1411fs RefSeq GRCh38/hg38
NM_001407472.1 chr5:g.(112840976_112840977) c.(4231_4230) p.S1411fs RefSeq GRCh38/hg38
NM_000038 chr5:g.(112839824_112839825) c.(4231_4230) p.S1411fs RefSeq GRCh38/hg38
NM_001354898.2 chr5:g.(112839899_112839900) c.(4231_4230) p.S1411fs RefSeq GRCh38/hg38
NM_001127510.2 chr5:g.(112839824_112839825) c.(4231_4230) p.S1411fs RefSeq GRCh38/hg38
NM_001407450.1 chr5:g.(112839824_112839825) c.(4231_4230) p.S1411fs RefSeq GRCh38/hg38
NM_001407471.1 chr5:g.(112840976_112840977) c.(4231_4230) p.S1411fs RefSeq GRCh38/hg38
NM_001354895.2 chr5:g.(112839824_112839825) c.(4231_4230) p.S1411fs RefSeq GRCh38/hg38
NM_000038.6 chr5:g.(112839824_112839825) c.(4231_4230) p.S1411fs RefSeq GRCh38/hg38
NM_001127510 chr5:g.(112839824_112839825) c.(4231_4230) p.S1411fs RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
APC S1411fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor