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Gene TP53
Variant H179Y
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions TP53 H179Y lies within the DNA-binding domain of the Tp53 protein (PMID: 15510160). H179Y confers a loss of function to the Tp53 protein as indicated by decreased transactivation of Tp53 targets, decreased growth suppression activity, decreased suppression of Nrf2 expression, increased Ccna1 and Cdk4 expression and cell proliferation in culture (PMID: 17530187, PMID: 12509279, PMID: 26497680), and increased proliferation, migration, invasion, and protein stability in culture and increases binding to Eif4a1 and Ruvbl2 (PMID: 37030635).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon5 TP53 H179Y

TP53 mutant TP53 inact mut TP53 H179Y

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Transcript NM_000546.6
gDNA chr17:g.7675077G>A
cDNA c.535C>T
Protein p.H179Y
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001126112 chr17:g.7675077G>A c.535C>T p.H179Y RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7675077G>A c.535C>T p.H179Y RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7675077G>A c.535C>T p.H179Y RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7675077G>A c.535C>T p.H179Y RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7675077G>A c.535C>T p.H179Y RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7675077G>A c.535C>T p.H179Y RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7675077G>A c.535C>T p.H179Y RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7675077G>A c.535C>T p.H179Y RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7675077G>A c.535C>T p.H179Y RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7675077G>A c.535C>T p.H179Y RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7675077G>A c.535C>T p.H179Y RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7675077G>A c.535C>T p.H179Y RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7675077G>A c.535C>T p.H179Y RefSeq GRCh38/hg38
NM_001126114 chr17:g.7675077G>A c.535C>T p.H179Y RefSeq GRCh38/hg38
NM_001126113 chr17:g.7675077G>A c.535C>T p.H179Y RefSeq GRCh38/hg38
NM_000546 chr17:g.7675077G>A c.535C>T p.H179Y RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7675077G>A c.535C>T p.H179Y RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References