DNMT3A V785M
Gene Variant Detail

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Gene DNMT3A
Variant V785M
Impact List missense
Protein Effect unknown
Gene Variant Descriptions DNMT3A V785M lies within the SAM-dependent MTase C5-type domain of the Dnmt3a protein (UniProt.org). V785M has been identified in sequencing studies (PMID: 22490330), but has not been biochemically characterized and therefore, its effect on Dnmt3a protein function is unknown (PubMed, Jun 2025).
Associated Drug Resistance
Category Variants Paths

DNMT3A mutant DNMT3A V785M

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Transcript NM_022552.5
gDNA chr2:g.25239185C>T
cDNA c.2353G>A
Protein p.V785M
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_017003526 chr2:g.25239185C>T c.2353G>A p.V785M RefSeq GRCh38/hg38
NM_022552.5 chr2:g.25239185C>T c.2353G>A p.V785M RefSeq GRCh38/hg38
NM_175629 chr2:g.25239185C>T c.2353G>A p.V785M RefSeq GRCh38/hg38
XM_017003526.2 chr2:g.25239185C>T c.2353G>A p.V785M RefSeq GRCh38/hg38
XM_005264175.6 chr2:g.25239185C>T c.2353G>A p.V785M RefSeq GRCh38/hg38
XM_047443593.1 chr2:g.25239185C>T c.2353G>A p.V785M RefSeq GRCh38/hg38
XM_005264175 chr2:g.25239185C>T c.2353G>A p.V785M RefSeq GRCh38/hg38
XM_005264175.5 chr2:g.25239185C>T c.2353G>A p.V785M RefSeq GRCh38/hg38
NM_175629.2 chr2:g.25239185C>T c.2353G>A p.V785M RefSeq GRCh38/hg38
XM_017003526.1 chr2:g.25239185C>T c.2353G>A p.V785M RefSeq GRCh38/hg38
NM_022552.4 chr2:g.25239185C>T c.2353G>A p.V785M RefSeq GRCh38/hg38
NM_022552 chr2:g.25239185C>T c.2353G>A p.V785M RefSeq GRCh38/hg38
NM_175629.2 chr2:g.25239185C>T c.2353G>A p.V785M RefSeq GRCh38/hg38

Filtering

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References