HRAS T58I
Gene Variant Detail

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Gene HRAS
Variant T58I
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions HRAS T58I does not lie within any known functional domains of the Hras protein (UniProt.org). T58I results in an increased GDP dissociation rate, moderately decreased GTP hydrolysis activity, remains sensitive to GAP stimulation, and exhibits decreased binding to RAF in in vitro assays, leading to the accumulation of the GTP-bound state and activation of downstream signaling in culture (PMID: 20949621).
Associated Drug Resistance
Category Variants Paths

HRAS mutant HRAS act mut HRAS T58I

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Transcript NM_005343.4
gDNA chr11:g.533883G>A
cDNA c.173C>T
Protein p.T58I
Source Database RefSeq
Genome Build GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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