HRAS T58I
Gene Variant Detail

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Gene HRAS
Variant T58I
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions HRAS T58I does not lie within any known functional domains of the Hras protein (UniProt.org). T58I results in an increased GDP dissociation rate, moderately decreased GTP hydrolysis activity, remains sensitive to GAP stimulation, and exhibits decreased binding to RAF in in vitro assays, leading to the accumulation of the GTP-bound state and activation of downstream signaling in culture (PMID: 20949621).
Associated Drug Resistance
Category Variants Paths

HRAS mutant HRAS act mut HRAS T58I

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Transcript NM_005343.4
gDNA chr11:g.533883G>A
cDNA c.173C>T
Protein p.T58I
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_005343.3 chr11:g.533883G>A c.173C>T p.T58I RefSeq GRCh38/hg38
NM_005343.4 chr11:g.533883G>A c.173C>T p.T58I RefSeq GRCh38/hg38
NM_176795 chr11:g.533883G>A c.173C>T p.T58I RefSeq GRCh38/hg38
NM_001130442.2 chr11:g.533883G>A c.173C>T p.T58I RefSeq GRCh38/hg38
NM_001130442.3 chr11:g.533883G>A c.173C>T p.T58I RefSeq GRCh38/hg38
NM_176795.5 chr11:g.533883G>A c.173C>T p.T58I RefSeq GRCh38/hg38
NM_176795.4 chr11:g.533883G>A c.173C>T p.T58I RefSeq GRCh38/hg38
NM_005343 chr11:g.533883G>A c.173C>T p.T58I RefSeq GRCh38/hg38
NM_001130442 chr11:g.533883G>A c.173C>T p.T58I RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
HRAS T58I gain of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor PIK3CB inhibitor PIK3CD inhibitor PIK3CG inhibitor RAS Inhibitor (Pan)