PIK3CA P124L
Gene Variant Detail

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Gene PIK3CA
Variant P124L
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions PIK3CA P124L does not lie within any known functional domains of the Pik3ca protein (UniProt.org). P124L results in activation of Pik3ca signaling as indicated by increased Akt phosphorylation, increased colony formation, and increased cell migration in cell culture (PMID: 22430209).
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA act mut PIK3CA P124L

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Transcript NM_006218.4
gDNA chr3:g.179199708C>T
cDNA c.371C>T
Protein p.P124L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006713658.4 chr3:g.179199708C>T c.371C>T p.P124L RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179199708C>T c.371C>T p.P124L RefSeq GRCh38/hg38
NM_006218.4 chr3:g.179199708C>T c.371C>T p.P124L RefSeq GRCh38/hg38
NM_006218.3 chr3:g.179199708C>T c.371C>T p.P124L RefSeq GRCh38/hg38
XM_011512894.2 chr3:g.179199708C>T c.371C>T p.P124L RefSeq GRCh38/hg38
XM_006713658 chr3:g.179199708C>T c.371C>T p.P124L RefSeq GRCh38/hg38
NM_006218 chr3:g.179199708C>T c.371C>T p.P124L RefSeq GRCh38/hg38
XM_011512894 chr3:g.179199708C>T c.371C>T p.P124L RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries