PIK3CA D549Y
Gene Variant Detail

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Gene PIK3CA
Variant D549Y
Impact List missense
Protein Effect unknown
Gene Variant Descriptions PIK3CA D549Y lies within the PIK helical domain of the Pik3ca protein (UniProt.org). D549Y has been identified in the scientific literature (PMID: 29106415, PMID: 26270481), but has not been biochemically characterized and therefore, its effect on Pik3ca protein function is unknown (PubMed, Aug 2025).
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA exon10 PIK3CA D549Y

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Transcript NM_006218.4
gDNA chr3:g.179218315G>T
cDNA c.1645G>T
Protein p.D549Y
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_006218.4 chr3:g.179218315G>T c.1645G>T p.D549Y RefSeq GRCh38/hg38
XM_006713658 chr3:g.179218315G>T c.1645G>T p.D549Y RefSeq GRCh38/hg38
XM_011512894.2 chr3:g.179218315G>T c.1645G>T p.D549Y RefSeq GRCh38/hg38
NM_006218 chr3:g.179218315G>T c.1645G>T p.D549Y RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179218315G>T c.1645G>T p.D549Y RefSeq GRCh38/hg38
XM_011512894 chr3:g.179218315G>T c.1645G>T p.D549Y RefSeq GRCh38/hg38
XM_006713658.4 chr3:g.179218315G>T c.1645G>T p.D549Y RefSeq GRCh38/hg38
NM_006218.3 chr3:g.179218315G>T c.1645G>T p.D549Y RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
PIK3CA D549Y urinary bladder cancer decreased response Pictilisib Preclinical - Pdx Actionable In a preclinical study, Pictilisib (GDC-0941) demonstrated limited tumor growth inhibition and survival benefit in patient-derived xenograft (PDX) models of bladder cancer harboring PIK3CA D549Y (PMID: 28808038). 28808038