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Gene | RAD51C |
Variant | G264V |
Impact List | missense |
Protein Effect | no effect |
Gene Variant Descriptions | RAD51C G264V does not lie within any known functional domains of the Rad51c protein (UniProt.org). G264V demonstrates rescue of mitomycin C hypersensitivity and Rad51 foci formation similar to wild-type Rad51c in culture (PMID: 20400964). |
Associated Drug Resistance | |
Category Variants Paths |
RAD51C mutant RAD51C G264V |
Transcript | NM_058216.3 |
gDNA | chr17:g.58709944G>T |
cDNA | c.791G>T |
Protein | p.G264V |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
XM_006722001 | chr17:g.58709944G>T | c.791G>T | p.G264V | RefSeq | GRCh38/hg38 |
NM_058216.2 | chr17:g.58709944G>T | c.791G>T | p.G264V | RefSeq | GRCh38/hg38 |
XM_006722002.5 | chr17:g.58709944G>T | c.791G>T | p.G264V | RefSeq | GRCh38/hg38 |
NM_058216.3 | chr17:g.58709944G>T | c.791G>T | p.G264V | RefSeq | GRCh38/hg38 |
XM_006722001.5 | chr17:g.58709944G>T | c.791G>T | p.G264V | RefSeq | GRCh38/hg38 |
XM_006722002 | chr17:g.58709944G>T | c.791G>T | p.G264V | RefSeq | GRCh38/hg38 |
XM_006722002.4 | chr17:g.58709944G>T | c.791G>T | p.G264V | RefSeq | GRCh38/hg38 |
XM_006722001.4 | chr17:g.58709944G>T | c.791G>T | p.G264V | RefSeq | GRCh38/hg38 |
NM_058216 | chr17:g.58709944G>T | c.791G>T | p.G264V | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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