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Gene RAD51C
Variant D159N
Impact List missense
Protein Effect unknown
Gene Variant Descriptions RAD51C D159N does not lie within any known functional domains of the Rad51c protein (UniProt.org). D159N demonstrates partial rescue of mitomycin C hypersensitivity in chicken cells and Rad51 foci formation similar to wild-type Rad51c in human cells in culture (PMID: 20400964), but in another study results in decreased binding to Brca2, Palb2, Rad51 (PMID: 24141787), and Rad51d and demonstrates loss of interaction with Xrcc3 in cell culture (PMID: 37253112), and binds to Rad51b and Rad51c at reduced levels but to Xrcc3 similar to wild-type protein in a yeast assay (PMID: 36099300), and therefore, its effect on Rad51c protein function is unknown.
Associated Drug Resistance
Category Variants Paths

RAD51C mutant RAD51C D159N

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Transcript NM_058216.3
gDNA chr17:g.58696763G>A
cDNA c.475G>A
Protein p.D159N
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_058216 chr17:g.58696763G>A c.475G>A p.D159N RefSeq GRCh38/hg38
XM_006722001.5 chr17:g.58696763G>A c.475G>A p.D159N RefSeq GRCh38/hg38
XM_006722002.4 chr17:g.58696763G>A c.475G>A p.D159N RefSeq GRCh38/hg38
NM_058216.3 chr17:g.58696763G>A c.475G>A p.D159N RefSeq GRCh38/hg38
XM_006722001 chr17:g.58696763G>A c.475G>A p.D159N RefSeq GRCh38/hg38
XM_006722002 chr17:g.58696763G>A c.475G>A p.D159N RefSeq GRCh38/hg38
XM_006722001.4 chr17:g.58696763G>A c.475G>A p.D159N RefSeq GRCh38/hg38
NM_058216.2 chr17:g.58696763G>A c.475G>A p.D159N RefSeq GRCh38/hg38
XM_047436505.1 chr17:g.58696763G>A c.475G>A p.D159N RefSeq GRCh38/hg38
XM_006722002.5 chr17:g.58696763G>A c.475G>A p.D159N RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References