Gene Variant Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Gene RAD51C
Variant D159N
Impact List missense
Protein Effect unknown
Gene Variant Descriptions RAD51C D159N does not lie within any known functional domains of the Rad51c protein (UniProt.org). D159N demonstrates partial rescue of mitomycin C hypersensitivity in chicken cells and Rad51 foci formation similar to wild-type Rad51c in human cells in culture (PMID: 20400964), but in another study results in decreased binding to Brca2, Palb2, Rad51 (PMID: 24141787), and Rad51d and demonstrates loss of interaction with Xrcc3 in cell culture (PMID: 37253112), and binds to Rad51b and Rad51c at reduced levels but to Xrcc3 similar to wild-type protein in a yeast assay (PMID: 36099300), and therefore, its effect on Rad51c protein function is unknown.
Associated Drug Resistance
Category Variants Paths

RAD51C mutant RAD51C D159N

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Transcript NM_058216.3
gDNA chr17:g.58696763G>A
cDNA c.475G>A
Protein p.D159N
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006722002.5 chr17:g.58696763G>A c.475G>A p.D159N RefSeq GRCh38/hg38
XM_006722001.4 chr17:g.58696763G>A c.475G>A p.D159N RefSeq GRCh38/hg38
XM_047436505.1 chr17:g.58696763G>A c.475G>A p.D159N RefSeq GRCh38/hg38
NM_058216 chr17:g.58696763G>A c.475G>A p.D159N RefSeq GRCh38/hg38
NM_058216.3 chr17:g.58696763G>A c.475G>A p.D159N RefSeq GRCh38/hg38
XM_006722001 chr17:g.58696763G>A c.475G>A p.D159N RefSeq GRCh38/hg38
XM_006722002.4 chr17:g.58696763G>A c.475G>A p.D159N RefSeq GRCh38/hg38
NM_058216.2 chr17:g.58696763G>A c.475G>A p.D159N RefSeq GRCh38/hg38
XM_006722001.5 chr17:g.58696763G>A c.475G>A p.D159N RefSeq GRCh38/hg38
XM_006722002 chr17:g.58696763G>A c.475G>A p.D159N RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References