Gene Variant Detail

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Gene FGFR2
Variant R6P
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions FGFR2 R6P does not lie within any known functional domains of the Fgfr2 protein (UniProt.org). R6P results in proliferation similar to wild-type Fgfr2 in a competition assay and transformation activity similar to wild-type in cultured cells (PMID: 34272467), and therefore, is predicted to have no effect on Fgfr2 protein function.
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 R6P

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Transcript NM_000141.5
gDNA chr10:g.121593801C>G
cDNA c.17G>C
Protein p.R6P
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000141 chr10:g.121593801C>G c.17G>C p.R6P RefSeq GRCh38/hg38
NM_001144919.1 chr10:g.121593801C>G c.17G>C p.R6P RefSeq GRCh38/hg38
NM_001144916.2 chr10:g.121593801C>G c.17G>C p.R6P RefSeq GRCh38/hg38
NM_023029 chr10:g.121593801C>G c.17G>C p.R6P RefSeq GRCh38/hg38
NM_001144917 chr10:g.121593801C>G c.17G>C p.R6P RefSeq GRCh38/hg38
NM_001144919.2 chr10:g.121593801C>G c.17G>C p.R6P RefSeq GRCh38/hg38
NM_001144918.1 chr10:g.121593801C>G c.17G>C p.R6P RefSeq GRCh38/hg38
NM_001144917.1 chr10:g.121593801C>G c.17G>C p.R6P RefSeq GRCh38/hg38
NM_022970.4 chr10:g.121593801C>G c.17G>C p.R6P RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121593801C>G c.17G>C p.R6P RefSeq GRCh38/hg38
NM_001144914.1 chr10:g.121593801C>G c.17G>C p.R6P RefSeq GRCh38/hg38
NM_001144918.2 chr10:g.121593801C>G c.17G>C p.R6P RefSeq GRCh38/hg38
NM_001320658 chr10:g.121593801C>G c.17G>C p.R6P RefSeq GRCh38/hg38
NM_022970 chr10:g.121593801C>G c.17G>C p.R6P RefSeq GRCh38/hg38
NM_023029.2 chr10:g.121593801C>G c.17G>C p.R6P RefSeq GRCh38/hg38
NM_001144915.1 chr10:g.121593801C>G c.17G>C p.R6P RefSeq GRCh38/hg38
NM_001144913 chr10:g.121593801C>G c.17G>C p.R6P RefSeq GRCh38/hg38
NM_001320658.1 chr10:g.121593801C>G c.17G>C p.R6P RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121593801C>G c.17G>C p.R6P RefSeq GRCh38/hg38
NM_001144917.2 chr10:g.121593801C>G c.17G>C p.R6P RefSeq GRCh38/hg38
NM_001144914 chr10:g.121593801C>G c.17G>C p.R6P RefSeq GRCh38/hg38
NM_001144914.1 chr10:g.121593801C>G c.17G>C p.R6P RefSeq GRCh38/hg38
NM_001144915 chr10:g.121593801C>G c.17G>C p.R6P RefSeq GRCh38/hg38
NM_001144919 chr10:g.121593801C>G c.17G>C p.R6P RefSeq GRCh38/hg38
NM_022970.3 chr10:g.121593801C>G c.17G>C p.R6P RefSeq GRCh38/hg38
NM_000141.5 chr10:g.121593801C>G c.17G>C p.R6P RefSeq GRCh38/hg38
NM_001320658.2 chr10:g.121593801C>G c.17G>C p.R6P RefSeq GRCh38/hg38
NM_001144916 chr10:g.121593801C>G c.17G>C p.R6P RefSeq GRCh38/hg38
NM_000141.4 chr10:g.121593801C>G c.17G>C p.R6P RefSeq GRCh38/hg38
NM_001144915.2 chr10:g.121593801C>G c.17G>C p.R6P RefSeq GRCh38/hg38
NM_001144918 chr10:g.121593801C>G c.17G>C p.R6P RefSeq GRCh38/hg38
NM_023029.2 chr10:g.121593801C>G c.17G>C p.R6P RefSeq GRCh38/hg38
NM_001144916.1 chr10:g.121593801C>G c.17G>C p.R6P RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Protein Effect Treatment Approaches
FGFR2 R6P no effect - predicted