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Gene ROS1
Variant F2075C
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ROS1 F2075C lies within the protein kinase domain of the Ros1 protein (UniProt.org). F2075C has been demonstrated to confer resistance to ROS1 tyrosine kinase inhibitors in the context of a ROS1 fusion in culture (PMID: 28717217), but has not been biochemically characterized and therefore, its effect on Ros1 protein function is unknown (PubMed, Apr 2024).
Associated Drug Resistance Y
Category Variants Paths

ROS1 mutant ROS1 F2075C

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Transcript NM_002944.3
gDNA chr6:g.117311029A>C
cDNA c.6224T>G
Protein p.F2075C
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002944.2 chr6:g.117311029A>C c.6224T>G p.F2075C RefSeq GRCh38/hg38
NM_002944 chr6:g.117311029A>C c.6224T>G p.F2075C RefSeq GRCh38/hg38
NM_002944.3 chr6:g.117311029A>C c.6224T>G p.F2075C RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References