FLT3 F621L
Gene Variant Detail

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Gene FLT3
Variant F621L
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FLT3 F621L lies within the protein kinase domain of the Flt3 protein (UniProt.org). F621L has been identified in the scientific literature (PMID: 22858906), but has not been biochemically characterized and therefore, its effect on Flt3 protein function is unknown (PubMed, Sep 2025).
Associated Drug Resistance Y
Category Variants Paths

FLT3 mutant FLT3 exon15 FLT3 F621L

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Transcript NM_004119.3
gDNA chr13:g.28033968A>G
cDNA c.1861T>C
Protein p.F621L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004119 chr13:g.28033968A>G c.1861T>C p.F621L RefSeq GRCh38/hg38
NM_004119.3 chr13:g.28033968A>G c.1861T>C p.F621L RefSeq GRCh38/hg38
NM_004119.2 chr13:g.28033968A>G c.1861T>C p.F621L RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References