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Gene FGFR2
Variant W290*
Impact List nonsense
Protein Effect loss of function - predicted
Gene Variant Descriptions FGFR2 W290* results in a premature truncation of the Fgfr2 protein at amino acid 290 of 821 (UniProt.org). Due to the loss of the protein kinase domain (UniProt.org), W290* is predicted to lead to a loss of Fgfr2 protein function.
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 exon7 FGFR2 W290*

FGFR2 mutant FGFR2 inact mut FGFR2 W290*

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Transcript NM_000141.5
gDNA chr10:g.121520049C>T
cDNA c.869G>A
Protein p.W290*
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001320658 chr10:g.121520049C>T c.869G>A p.W290* RefSeq GRCh38/hg38
NM_001144917.1 chr10:g.121520049C>T c.869G>A p.W290* RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121520049C>T c.869G>A p.W290* RefSeq GRCh38/hg38
NM_001320658.1 chr10:g.121520049C>T c.869G>A p.W290* RefSeq GRCh38/hg38
NM_022970.4 chr10:g.121520049C>T c.869G>A p.W290* RefSeq GRCh38/hg38
NM_001144913 chr10:g.121520049C>T c.869G>A p.W290* RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121520049C>T c.869G>A p.W290* RefSeq GRCh38/hg38
NM_001320658.2 chr10:g.121520049C>T c.869G>A p.W290* RefSeq GRCh38/hg38
NM_000141.4 chr10:g.121520049C>T c.869G>A p.W290* RefSeq GRCh38/hg38
NM_000141 chr10:g.121520049C>T c.869G>A p.W290* RefSeq GRCh38/hg38
NM_022970.3 chr10:g.121520049C>T c.869G>A p.W290* RefSeq GRCh38/hg38
NM_001144917 chr10:g.121520049C>T c.869G>A p.W290* RefSeq GRCh38/hg38
NM_000141.5 chr10:g.121520049C>T c.869G>A p.W290* RefSeq GRCh38/hg38
NM_022970 chr10:g.121520049C>T c.869G>A p.W290* RefSeq GRCh38/hg38
NM_001144917.2 chr10:g.121520049C>T c.869G>A p.W290* RefSeq GRCh38/hg38

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References