Gene Variant Detail

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Gene FGFR1
Variant C381Y
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions FGFR1 C381Y lies within the transmembrane domain of the Fgfr1 protein (UniProt.org). C381Y has not been biochemically characterized, but results in similar cell proliferation and viability levels as wild-type Fgfr1 in cultured cells (PMID: 29533785), and therefore, is predicted to have no effect on Fgfr1 protein function.
Associated Drug Resistance
Category Variants Paths

FGFR1 mutant FGFR1 C381Y

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Transcript NM_023110.3
gDNA chr8:g.38419675C>T
cDNA c.1142G>A
Protein p.C381Y
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001174064.1 chr8:g.38419651C>T c.1142G>A p.C381Y RefSeq GRCh38/hg38
XM_024447097.1 chr8:g.38419651C>T c.1142G>A p.C381Y RefSeq GRCh38/hg38
XM_047421570.1 chr8:g.38419675C>T c.1142G>A p.C381Y RefSeq GRCh38/hg38
XM_006716303 chr8:g.38419675C>T c.1142G>A p.C381Y RefSeq GRCh38/hg38
NM_001174064 chr8:g.38419651C>T c.1142G>A p.C381Y RefSeq GRCh38/hg38
NM_001174063.1 chr8:g.38419675C>T c.1142G>A p.C381Y RefSeq GRCh38/hg38
NM_023110.2 chr8:g.38419675C>T c.1142G>A p.C381Y RefSeq GRCh38/hg38
XM_024447097.1 chr8:g.38419651C>T c.1142G>A p.C381Y RefSeq GRCh38/hg38
XM_006716304 chr8:g.38419675C>T c.1142G>A p.C381Y RefSeq GRCh38/hg38
XM_017013221.1 chr8:g.38419675C>T c.1142G>A p.C381Y RefSeq GRCh38/hg38
XM_017013221.2 chr8:g.38419675C>T c.1142G>A p.C381Y RefSeq GRCh38/hg38
XM_006716303.4 chr8:g.38419675C>T c.1142G>A p.C381Y RefSeq GRCh38/hg38
NM_001174063.2 chr8:g.38419675C>T c.1142G>A p.C381Y RefSeq GRCh38/hg38
XM_006716309 chr8:g.38419651C>T c.1142G>A p.C381Y RefSeq GRCh38/hg38
XM_006716303.3 chr8:g.38419675C>T c.1142G>A p.C381Y RefSeq GRCh38/hg38
XM_006716304.2 chr8:g.38419675C>T c.1142G>A p.C381Y RefSeq GRCh38/hg38
XM_006716304.1 chr8:g.38419675C>T c.1142G>A p.C381Y RefSeq GRCh38/hg38
NM_023110.3 chr8:g.38419675C>T c.1142G>A p.C381Y RefSeq GRCh38/hg38
XM_017013222.2 chr8:g.38419675C>T c.1142G>A p.C381Y RefSeq GRCh38/hg38
NM_001174064.2 chr8:g.38419651C>T c.1142G>A p.C381Y RefSeq GRCh38/hg38
XM_017013221 chr8:g.38419675C>T c.1142G>A p.C381Y RefSeq GRCh38/hg38
NM_001174063 chr8:g.38419675C>T c.1142G>A p.C381Y RefSeq GRCh38/hg38
NM_023110 chr8:g.38419675C>T c.1142G>A p.C381Y RefSeq GRCh38/hg38
XM_017013222 chr8:g.38419675C>T c.1142G>A p.C381Y RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References