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Gene FGFR1
Variant L122F
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions FGFR1 L122F lies within the extracellular domain of the Fgfr1 protein (UniProt.org). L122F has not been biochemically characterized, but results in similar cell proliferation and viability levels as wild-type Fgfr1 in cultured cells (PMID: 29533785), and therefore, is predicted to have no effect on Fgfr1 protein function.
Associated Drug Resistance
Category Variants Paths

FGFR1 mutant FGFR1 L122F

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Transcript NM_023110.3
gDNA chr8:g.38428430G>A
cDNA c.364C>T
Protein p.L122F
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_015850.3 chr8:g.38428430G>A c.364C>T p.L122F RefSeq GRCh38/hg38
XM_017013224 chr8:g.38428430G>A c.364C>T p.L122F RefSeq GRCh38/hg38
XM_017013222 chr8:g.38428430G>A c.364C>T p.L122F RefSeq GRCh38/hg38
NM_001354369.2 chr8:g.38428430G>A c.364C>T p.L122F RefSeq GRCh38/hg38
XM_017013222.2 chr8:g.38428430G>A c.364C>T p.L122F RefSeq GRCh38/hg38
NM_023110 chr8:g.38428430G>A c.364C>T p.L122F RefSeq GRCh38/hg38
XM_006716304.2 chr8:g.38428430G>A c.364C>T p.L122F RefSeq GRCh38/hg38
XM_017013225 chr8:g.38428430G>A c.364C>T p.L122F RefSeq GRCh38/hg38
NM_001354369.1 chr8:g.38428430G>A c.364C>T p.L122F RefSeq GRCh38/hg38
XM_047421569.1 chr8:g.38428430G>A c.364C>T p.L122F RefSeq GRCh38/hg38
NM_015850.4 chr8:g.38428430G>A c.364C>T p.L122F RefSeq GRCh38/hg38
NM_015850 chr8:g.38428430G>A c.364C>T p.L122F RefSeq GRCh38/hg38
XM_006716303.3 chr8:g.38428430G>A c.364C>T p.L122F RefSeq GRCh38/hg38
XM_006716307.2 chr8:g.38428430G>A c.364C>T p.L122F RefSeq GRCh38/hg38
NM_001354367.2 chr8:g.38428430G>A c.364C>T p.L122F RefSeq GRCh38/hg38
XM_006716306 chr8:g.38428430G>A c.364C>T p.L122F RefSeq GRCh38/hg38
XM_006716303.4 chr8:g.38428430G>A c.364C>T p.L122F RefSeq GRCh38/hg38
XM_006716307 chr8:g.38428430G>A c.364C>T p.L122F RefSeq GRCh38/hg38
XM_017013223 chr8:g.38428430G>A c.364C>T p.L122F RefSeq GRCh38/hg38
XM_017013225.2 chr8:g.38428430G>A c.364C>T p.L122F RefSeq GRCh38/hg38
XM_047421570.1 chr8:g.38428430G>A c.364C>T p.L122F RefSeq GRCh38/hg38
XM_006716304.1 chr8:g.38428430G>A c.364C>T p.L122F RefSeq GRCh38/hg38
XM_017013221.1 chr8:g.38428430G>A c.364C>T p.L122F RefSeq GRCh38/hg38
XM_006716307.1 chr8:g.38428430G>A c.364C>T p.L122F RefSeq GRCh38/hg38
NM_001174065 chr8:g.38428430G>A c.364C>T p.L122F RefSeq GRCh38/hg38
XM_006716303 chr8:g.38428430G>A c.364C>T p.L122F RefSeq GRCh38/hg38
NM_001174065.2 chr8:g.38428430G>A c.364C>T p.L122F RefSeq GRCh38/hg38
XM_006716304 chr8:g.38428430G>A c.364C>T p.L122F RefSeq GRCh38/hg38
XM_017013225.3 chr8:g.38428430G>A c.364C>T p.L122F RefSeq GRCh38/hg38
NM_001174063.2 chr8:g.38428430G>A c.364C>T p.L122F RefSeq GRCh38/hg38
NM_023110.2 chr8:g.38428430G>A c.364C>T p.L122F RefSeq GRCh38/hg38
XM_017013221 chr8:g.38428430G>A c.364C>T p.L122F RefSeq GRCh38/hg38
XM_017013224.2 chr8:g.38428430G>A c.364C>T p.L122F RefSeq GRCh38/hg38
NM_023110.3 chr8:g.38428430G>A c.364C>T p.L122F RefSeq GRCh38/hg38
NM_001410922.1 chr8:g.38428430G>A c.364C>T p.L122F RefSeq GRCh38/hg38
XM_017013221.2 chr8:g.38428430G>A c.364C>T p.L122F RefSeq GRCh38/hg38
NM_001174063 chr8:g.38428430G>A c.364C>T p.L122F RefSeq GRCh38/hg38
NM_001354367.1 chr8:g.38428430G>A c.364C>T p.L122F RefSeq GRCh38/hg38
NM_001174063.1 chr8:g.38428430G>A c.364C>T p.L122F RefSeq GRCh38/hg38
NM_001174065.1 chr8:g.38428430G>A c.364C>T p.L122F RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
FGFR1 L122F no effect - predicted