Gene Variant Detail

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Gene FGFR1
Variant R822C
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions FGFR1 R822C lies within the cytoplasmic domain of the Fgfr1 protein (UniProt.org). R822C has not been biochemically characterized, but results in similar cell proliferation and viability levels as wild-type Fgfr1 in cultured cells (PMID: 29533785), and therefore, is predicted to have no effect on Fgfr1 protein function.
Associated Drug Resistance
Category Variants Paths

FGFR1 mutant FGFR1 R822C

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Transcript NM_023110.3
gDNA chr8:g.38413633G>A
cDNA c.2464C>T
Protein p.R822C
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006716303.3 chr8:g.38412422_38412424delCGGinsTGT c.2464_2466delCGGinsTGT p.R822C RefSeq GRCh38/hg38
XM_011544445.2 chr8:g.38412515_38412517delCGAinsTGT c.2464_2466delCGAinsTGT p.R822C RefSeq GRCh38/hg38
XM_017013221 chr8:g.38412422_38412424delCCGinsACA c.2464_2466delCGGinsTGT p.R822C RefSeq GRCh38/hg38
XM_006716304.2 chr8:g.38412422_38412424delCGGinsTGT c.2464_2466delCGGinsTGT p.R822C RefSeq GRCh38/hg38
XM_011544445.3 chr8:g.38412515_38412517delCGAinsTGT c.2464_2466delCGAinsTGT p.R822C RefSeq GRCh38/hg38
NM_023110.3 chr8:g.38413633G>A c.2464C>T p.R822C RefSeq GRCh38/hg38
XM_006716304.1 chr8:g.38412422_38412424delCGGinsTGT c.2464_2466delCGGinsTGT p.R822C RefSeq GRCh38/hg38
XM_011544444.2 chr8:g.38412515_38412517delCGAinsTGT c.2464_2466delCGAinsTGT p.R822C RefSeq GRCh38/hg38
XM_006716304 chr8:g.38412422_38412424delCCGinsACA c.2464_2466delCGGinsTGT p.R822C RefSeq GRCh38/hg38
XM_011544444.1 chr8:g.38412515_38412517delCGAinsTGT c.2464_2466delCGAinsTGT p.R822C RefSeq GRCh38/hg38
XM_006716303.4 chr8:g.38412422_38412424delCGGinsTGT c.2464_2466delCGGinsTGT p.R822C RefSeq GRCh38/hg38
XM_011544445 chr8:g.38412515_38412517delTCGinsACA c.2464_2466delCGAinsTGT p.R822C RefSeq GRCh38/hg38
NM_023110.2 chr8:g.38413633G>A c.2464C>T p.R822C RefSeq GRCh38/hg38
XM_017013221.1 chr8:g.38412422_38412424delCGGinsTGT c.2464_2466delCGGinsTGT p.R822C RefSeq GRCh38/hg38
NM_023110 chr8:g.38413633G>A c.2464C>T p.R822C RefSeq GRCh38/hg38
XM_011544444 chr8:g.38412515_38412517delTCGinsACA c.2464_2466delCGAinsTGT p.R822C RefSeq GRCh38/hg38
XM_006716303 chr8:g.38412422_38412424delCCGinsACA c.2464_2466delCGGinsTGT p.R822C RefSeq GRCh38/hg38
XM_017013221.2 chr8:g.38412422_38412424delCGGinsTGT c.2464_2466delCGGinsTGT p.R822C RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
FGFR1 R822C no effect - predicted