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Gene FGFR2
Variant C382Y
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions FGFR2 C382Y lies within the helical domain of the Fgfr2 protein (UniProt.org). C382Y has not been biochemically characterized, but results in similar cell proliferation and viability levels as wild-type Fgfr2 in cultured cells (PMID: 29533785), and therefore, is predicted to have no effect on Fgfr2 protein function.
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 C382Y

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Transcript NM_000141.5
gDNA chr10:g.121515259C>T
cDNA c.1145G>A
Protein p.C382Y
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001320658 chr10:g.121515259C>T c.1145G>A p.C382Y RefSeq GRCh38/hg38
NM_000141.5 chr10:g.121515259C>T c.1145G>A p.C382Y RefSeq GRCh38/hg38
NM_000141 chr10:g.121515259C>T c.1145G>A p.C382Y RefSeq GRCh38/hg38
NM_001320658.2 chr10:g.121515259C>T c.1145G>A p.C382Y RefSeq GRCh38/hg38
NM_000141.4 chr10:g.121515259C>T c.1145G>A p.C382Y RefSeq GRCh38/hg38
NM_001320658.1 chr10:g.121515259C>T c.1145G>A p.C382Y RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References