Gene Variant Detail

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Gene FGFR2
Variant K292M
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions FGFR2 K292M lies within Ig-like C2-type domain 3 of the Fgfr2 protein (UniProt.org). K292M has not been biochemically characterized, but results in similar cell proliferation and viability levels as wild-type Fgfr2 in cultured cells (PMID: 29533785), and therefore, is predicted to have no effect on Fgfr2 protein function.
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 exon7 FGFR2 K292M

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Transcript NM_000141.5
gDNA chr10:g.121520043T>A
cDNA c.875A>T
Protein p.K292M
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001320658 chr10:g.121520043T>A c.875A>T p.K292M RefSeq GRCh38/hg38
NM_001320658.2 chr10:g.121520043T>A c.875A>T p.K292M RefSeq GRCh38/hg38
NM_001320654.2 chr10:g.121500827_121500828delAAinsTG c.875_876delAAinsTG p.K292M RefSeq GRCh38/hg38
NM_001144917 chr10:g.121520043T>A c.875A>T p.K292M RefSeq GRCh38/hg38
NM_000141 chr10:g.121520043T>A c.875A>T p.K292M RefSeq GRCh38/hg38
NM_001320658.1 chr10:g.121520043T>A c.875A>T p.K292M RefSeq GRCh38/hg38
NM_000141.5 chr10:g.121520043T>A c.875A>T p.K292M RefSeq GRCh38/hg38
NM_001320654.1 chr10:g.121500827_121500828delAAinsTG c.875_876delAAinsTG p.K292M RefSeq GRCh38/hg38
NM_022970 chr10:g.121520043T>A c.875A>T p.K292M RefSeq GRCh38/hg38
NM_001144917.1 chr10:g.121520043T>A c.875A>T p.K292M RefSeq GRCh38/hg38
NM_001144913 chr10:g.121520043T>A c.875A>T p.K292M RefSeq GRCh38/hg38
NM_000141.4 chr10:g.121520043T>A c.875A>T p.K292M RefSeq GRCh38/hg38
NM_001320654 chr10:g.121500827_121500828delTTinsCA c.875_876delAAinsTG p.K292M RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121520043T>A c.875A>T p.K292M RefSeq GRCh38/hg38
NM_001144917.2 chr10:g.121520043T>A c.875A>T p.K292M RefSeq GRCh38/hg38
NM_022970.3 chr10:g.121520043T>A c.875A>T p.K292M RefSeq GRCh38/hg38
NM_022970.4 chr10:g.121520043T>A c.875A>T p.K292M RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121520043T>A c.875A>T p.K292M RefSeq GRCh38/hg38

Filtering

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries