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Gene FGFR2
Variant S436F
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions FGFR2 S436F lies within the cytoplasmic domain of the Fgfr2 protein (UniProt.org). S436F has not been biochemically characterized, but results in similar cell proliferation and viability levels as wild-type Fgfr2 in cultured cells (PMID: 29533785), and therefore, is predicted to have no effect on Fgfr2 protein function.
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 S436F

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Transcript NM_000141.5
gDNA chr10:g.121503922G>A
cDNA c.1307C>T
Protein p.S436F
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_022970 chr10:g.121503925_121503926delCTinsAA c.1306_1307delAGinsTT p.S436F RefSeq GRCh38/hg38
NM_022970.3 chr10:g.121503925_121503926delAGinsTT c.1306_1307delAGinsTT p.S436F RefSeq GRCh38/hg38
NM_000141.4 chr10:g.121503922G>A c.1307C>T p.S436F RefSeq GRCh38/hg38
NM_022970.4 chr10:g.121503925_121503926delAGinsTT c.1306_1307delAGinsTT p.S436F RefSeq GRCh38/hg38
NM_000141 chr10:g.121503922G>A c.1307C>T p.S436F RefSeq GRCh38/hg38
NM_001144913 chr10:g.121503925_121503926delCTinsAA c.1306_1307delAGinsTT p.S436F RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121503925_121503926delAGinsTT c.1306_1307delAGinsTT p.S436F RefSeq GRCh38/hg38
NM_000141.5 chr10:g.121503922G>A c.1307C>T p.S436F RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121503925_121503926delAGinsTT c.1306_1307delAGinsTT p.S436F RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References