Gene Variant Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Gene FGFR2
Variant V392M
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions FGFR2 V392M lies within the helical domain of the Fgfr2 protein (UniProt.org). V392M has not been biochemically characterized, but results in similar cell proliferation and viability levels as wild-type Fgfr2 in cultured cells (PMID: 29533785), and therefore, is predicted to have no effect on Fgfr2 protein function.
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 V392M

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Transcript NM_000141.5
gDNA chr10:g.121515230C>T
cDNA c.1174G>A
Protein p.V392M
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001320658 chr10:g.121515230C>T c.1174G>A p.V392M RefSeq GRCh38/hg38
XM_024447888.1 chr10:g.121503840_121503842delGTCinsATG c.1174_1176delGTCinsATG p.V392M RefSeq GRCh38/hg38
XM_024447888.2 chr10:g.121503840_121503842delGTCinsATG c.1174_1176delGTCinsATG p.V392M RefSeq GRCh38/hg38
XM_017015922 chr10:g.121503840_121503842delGACinsCAT c.1174_1176delGTCinsATG p.V392M RefSeq GRCh38/hg38
NM_001320658.1 chr10:g.121515230C>T c.1174G>A p.V392M RefSeq GRCh38/hg38
NM_000141.4 chr10:g.121515230C>T c.1174G>A p.V392M RefSeq GRCh38/hg38
NM_000141.5 chr10:g.121515230C>T c.1174G>A p.V392M RefSeq GRCh38/hg38
NM_000141 chr10:g.121515230C>T c.1174G>A p.V392M RefSeq GRCh38/hg38
NM_001320658.2 chr10:g.121515230C>T c.1174G>A p.V392M RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References