Gene Variant Detail

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Gene PIK3CA
Variant G451V
Impact List missense
Protein Effect unknown
Gene Variant Descriptions PIK3CA G451V lies within the C2 PI3K-type domain of the Pik3ca protein (UniProt.org). G451V results in increased cell proliferation and cell viability compared to wild-type Pik3ca in one of two different cell lines in culture (PMID: 29533785), but has not been biochemically characterized and therefore, its effect on Pik3ca protein function is unknown.
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA exon8 PIK3CA G451V

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Transcript NM_006218.4
gDNA chr3:g.179210286G>T
cDNA c.1352G>T
Protein p.G451V
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_006218.3 chr3:g.179210286G>T c.1352G>T p.G451V RefSeq GRCh38/hg38
XM_006713658 chr3:g.179210286G>T c.1352G>T p.G451V RefSeq GRCh38/hg38
NM_006218.4 chr3:g.179210286G>T c.1352G>T p.G451V RefSeq GRCh38/hg38
XM_011512894 chr3:g.179210286G>T c.1352G>T p.G451V RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179210286G>T c.1352G>T p.G451V RefSeq GRCh38/hg38
XM_006713658.4 chr3:g.179210286G>T c.1352G>T p.G451V RefSeq GRCh38/hg38
XM_011512894.2 chr3:g.179210286G>T c.1352G>T p.G451V RefSeq GRCh38/hg38
NM_006218 chr3:g.179210286G>T c.1352G>T p.G451V RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries