PIK3CA P366R
Gene Variant Detail

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Gene PIK3CA
Variant P366R
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions PIK3CA P366R lies within the C2 PI3K-type domain of the Pik3ca protein (UniProt.org). P366R results in increased transformation ability in two different cell lines (PMID: 29533785), and therefore, is predicted to lead to a gain of Pik3ca protein function.
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA act mut PIK3CA P366R

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Transcript NM_006218.4
gDNA chr3:g.179204540C>G
cDNA c.1097C>G
Protein p.P366R
Source Database RefSeq
Genome Build GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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