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Gene PIK3CA
Variant R975S
Impact List missense
Protein Effect unknown
Gene Variant Descriptions PIK3CA R975S lies within the PI3K/PI4K domain of the Pik3ca protein (UniProt.org). The functional effect of R975S is conflicting, as it results in cell proliferation, viability, migration, and Akt phosphorylation levels similar to wild-type Pik3ca (PMID: 29533785, PMID: 34779417), but modestly increased cell proliferation in another study (PMID: 23619167), and therefore, its effect on Pik3ca protein function is unknown.
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA exon20 PIK3CA R975S

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Transcript NM_006218.4
gDNA chr3:g.179230365A>C
cDNA c.2925A>C
Protein p.R975S
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011512894.2 chr3:g.179230365A>C c.2925A>C p.R975S RefSeq GRCh38/hg38
XM_006713658.4 chr3:g.179230365A>C c.2925A>C p.R975S RefSeq GRCh38/hg38
NM_006218 chr3:g.179230365A>C c.2925A>C p.R975S RefSeq GRCh38/hg38
NM_006218.3 chr3:g.179230365A>C c.2925A>C p.R975S RefSeq GRCh38/hg38
XM_006713658 chr3:g.179230365A>C c.2925A>C p.R975S RefSeq GRCh38/hg38
XM_011512894 chr3:g.179230365A>C c.2925A>C p.R975S RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179230365A>C c.2925A>C p.R975S RefSeq GRCh38/hg38
NM_006218.4 chr3:g.179230365A>C c.2925A>C p.R975S RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References