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Gene PIK3CA
Variant S629C
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions PIK3CA S629C lies within the PIK helical domain of the Pik3ca protein (UniProt.org). S629C results in increased transformation ability in two different cell lines in culture (PMID: 29533785), and therefore, is predicted to lead to a gain of Pik3ca protein function.
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA act mut PIK3CA S629C

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Transcript NM_006218.4
gDNA chr3:g.179219710C>G
cDNA c.1886C>G
Protein p.S629C
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_006218.3 chr3:g.179219710C>G c.1886C>G p.S629C RefSeq GRCh38/hg38
XM_011512894.2 chr3:g.179219710C>G c.1886C>G p.S629C RefSeq GRCh38/hg38
XM_006713658.4 chr3:g.179219710C>G c.1886C>G p.S629C RefSeq GRCh38/hg38
XM_006713658 chr3:g.179219710C>G c.1886C>G p.S629C RefSeq GRCh38/hg38
NM_006218 chr3:g.179219710C>G c.1886C>G p.S629C RefSeq GRCh38/hg38
XM_011512894 chr3:g.179219710C>G c.1886C>G p.S629C RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179219710C>G c.1886C>G p.S629C RefSeq GRCh38/hg38
NM_006218.4 chr3:g.179219710C>G c.1886C>G p.S629C RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
PIK3CA S629C gain of function - predicted Akt Inhibitor (Pan) Akt1 Inhibitor Akt2 Inhibitor mTOR Inhibitor mTORC1 Inhibitor mTORC2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor