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Gene RB1
Variant H483Y
Impact List missense
Protein Effect unknown
Gene Variant Descriptions RB1 H483Y lies within domain A of the Rb1 protein (UniProt.org). H483Y has been identified in the scientific literature (PMID: 29236940, PMID: 33539671), but has not been biochemically characterized and therefore, its effect on Rb1 protein function is unknown (PubMed, May 2024).
Associated Drug Resistance
Category Variants Paths

RB1 mutant RB1 H483Y

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Transcript NM_000321.3
gDNA chr13:g.48380190C>T
cDNA c.1447C>T
Protein p.H483Y
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000321.3 chr13:g.48380190C>T c.1447C>T p.H483Y RefSeq GRCh38/hg38
NM_000321 chr13:g.48380190C>T c.1447C>T p.H483Y RefSeq GRCh38/hg38
NM_000321.2 chr13:g.48380190C>T c.1447C>T p.H483Y RefSeq GRCh38/hg38
NM_001407165.1 chr13:g.48380190C>T c.1447C>T p.H483Y RefSeq GRCh38/hg38
NM_001407166.1 chr13:g.48380190C>T c.1447C>T p.H483Y RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RB1 H483Y Her2-receptor negative breast cancer predicted - resistant Letrozole + Ribociclib Case Reports/Case Series Actionable In a clinical case study, RB1 H483Y was identified in the circulating tumor DNA of a patient with estrogen receptor (ESR1)-positive, progesterone receptor (PGR)-positive, and Erbb2 (Her2)-negative, invasive ductal carcinoma at the time of disease progression after 13 months of Kisqali (ribociclib) and Femara (letrozole) combination treatment (PMID: 29236940). 29236940