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Gene PTEN
Variant A79T
Impact List missense
Protein Effect unknown
Gene Variant Descriptions PTEN A79T lies within the phosphatase tensin-type domain of the Pten protein (UniProt.org). A79T demonstrates Pten protein stability (PMID: 32366478, PMID: 32350270), suppression of Akt phosphorylation (PMID: 32350270), and cell proliferation and viability levels similar to wild-type Pten in culture (PMID: 29533785), however, fails to rescue spheroid formation (PMID: 32366478), and therefore, its effect on Pten protein function is unknown.
Associated Drug Resistance
Category Variants Paths

PTEN mutant PTEN A79T

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Transcript NM_000314.8
gDNA chr10:g.87931071G>A
cDNA c.235G>A
Protein p.A79T
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001304717.5 chr10:g.87864185G>A c.235G>A p.A79T RefSeq GRCh38/hg38
NM_001304717.2 chr10:g.87864185G>A c.235G>A p.A79T RefSeq GRCh38/hg38
NM_001304717 chr10:g.87864185G>A c.235G>A p.A79T RefSeq GRCh38/hg38
NM_000314.6 chr10:g.87931071G>A c.235G>A p.A79T RefSeq GRCh38/hg38
NM_000314 chr10:g.87931071G>A c.235G>A p.A79T RefSeq GRCh38/hg38
NM_000314.8 chr10:g.87931071G>A c.235G>A p.A79T RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References