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Gene PIK3CA
Variant V105_R108del
Impact List deletion
Protein Effect gain of function - predicted
Gene Variant Descriptions PIK3CA V105_R108del results in the deletion of four amino acids in the Pik3ca protein from amino acids 105 to 108 (UniProt.org). V105_R108del has not been biochemically characterized, but results in increased transformation ability in two different cell lines in culture (PMID: 29533785), and therefore, is predicted to lead to a gain of Pik3ca protein function.
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA act mut PIK3CA V105_R108del

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Transcript NM_006218.4
gDNA chr3:g.179199139_179199150del12
cDNA c.314_325del12
Protein p.V105_R108delVGNR
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006713658.5 chr3:g.179199139_179199150del12 c.314_325del12 p.V105_R108delVGNR RefSeq GRCh38/hg38
NM_006218.4 chr3:g.179199139_179199150del12 c.314_325del12 p.V105_R108delVGNR RefSeq GRCh38/hg38
XM_006713658 chr3:g.179199139_179199150del12 c.314_325del12 p.V105_R108delVGNR RefSeq GRCh38/hg38
NM_006218 chr3:g.179199139_179199150del12 c.314_325del12 p.V105_R108delVGNR RefSeq GRCh38/hg38
XM_011512894 chr3:g.179199139_179199150del12 c.314_325del12 p.V105_R108delVGNR RefSeq GRCh38/hg38
XM_011512894.2 chr3:g.179199139_179199150del12 c.314_325del12 p.V105_R108delVGNR RefSeq GRCh38/hg38
XM_006713658.4 chr3:g.179199139_179199150del12 c.314_325del12 p.V105_R108delVGNR RefSeq GRCh38/hg38
NM_006218.3 chr3:g.179199139_179199150del12 c.314_325del12 p.V105_R108delVGNR RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References