FGFR2 F386_A389del - Gene Variant Detail

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Gene FGFR2
Variant F386_A389del
Impact List deletion
Protein Effect no effect - predicted
Gene Variant Descriptions FGFR2 F386_A389del results in the deletion of four amino acids of the Fgfr2 protein from amino acids 386 to 389 (UniProt.org). F386_A389del has not been biochemically characterized, but results in similar cell proliferation and viability levels as wild-type Fgfr2 in cultured cells (PMID: 29533785), and therefore, it is predicted to have no effect on Fgfr2 protein function.
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 F386_A389del

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Transcript NM_000141.5
gDNA chr10:g.121515238_121515249del12
cDNA c.1157_1168del12
Protein p.F386_A389delFLIA
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_024447887.1 chr10:g.121503852_121503863del12 c.1156_1167del12 p.D386_M389delDTPM RefSeq GRCh38/hg38
NM_001144917.2 chr10:g.121500872_121500883del12 c.1157_1168del12 p.G386_K389delGIDK RefSeq GRCh38/hg38
NM_001320654.2 chr10:g.121496544_121496555del12 c.1156_1167del12 p.M386_L389delMEYL RefSeq GRCh38/hg38
NM_022970 chr10:g.121515240_121515251del12 c.1157_1168del12 p.V386_I389delVFLI RefSeq GRCh38/hg38
XM_017015920.2 chr10:g.121515297_121515308del12 c.1156_1167del12 p.E386_I389delEKEI RefSeq GRCh38/hg38
NM_023029 chr10:g.121503795_121503806del12 c.1158_1169del12 p.E386_R389delEFPR RefSeq GRCh38/hg38
XM_006717708 chr10:g.121515297_121515308del12 c.1156_1167del12 p.E386_I389delEKEI RefSeq GRCh38/hg38
NM_001144915.2 chr10:g.121503795_121503806del12 c.1158_1169del12 p.E386_R389delEFPR RefSeq GRCh38/hg38
XM_006717710.5 chr10:g.121515297_121515308del12 c.1156_1167del12 p.E386_I389delEKEI RefSeq GRCh38/hg38
XM_017015924 chr10:g.121500933_121500944del12 c.1156_1167del12 p.T386_K389delTLGK RefSeq GRCh38/hg38
XM_017015921.3 chr10:g.121515295_121515306del12 c.1156_1167del12 p.K386_T389delKEIT RefSeq GRCh38/hg38
XM_024447888.2 chr10:g.121503849_121503860del12 c.1156_1167del12 p.T386_L389delTPML RefSeq GRCh38/hg38
XM_017015925.2 chr10:g.121500929_121500940del12 c.1158_1169del12 p.K387_G390delKPLG RefSeq GRCh38/hg38
NM_001144917 chr10:g.121500872_121500883del12 c.1157_1168del12 p.G386_K389delGIDK RefSeq GRCh38/hg38
NM_001144917.1 chr10:g.121500872_121500883del12 c.1157_1168del12 p.G386_K389delGIDK RefSeq GRCh38/hg38
XM_006717708.4 chr10:g.121515297_121515308del12 c.1156_1167del12 p.E386_I389delEKEI RefSeq GRCh38/hg38
XM_024447891.1 chr10:g.121500935_121500946del12 c.1156_1167del12 p.L386_G389delLTLG RefSeq GRCh38/hg38
NM_001320654.1 chr10:g.121496544_121496555del12 c.1156_1167del12 p.M386_L389delMEYL RefSeq GRCh38/hg38
NM_001144919.1 chr10:g.121503799_121503810del12 c.1156_1167del12 p.W386_P389delWEFP RefSeq GRCh38/hg38
NM_022970.3 chr10:g.121515240_121515251del12 c.1157_1168del12 p.V386_I389delVFLI RefSeq GRCh38/hg38
NM_023029.2 chr10:g.121503795_121503806del12 c.1158_1169del12 p.E386_R389delEFPR RefSeq GRCh38/hg38
XM_024447890.1 chr10:g.121503855_121503866del12 c.1156_1167del12 p.A386_P389delADTP RefSeq GRCh38/hg38
XM_017015921 chr10:g.121515295_121515306del12 c.1156_1167del12 p.K386_T389delKEIT RefSeq GRCh38/hg38
NM_001320658.1 chr10:g.121515238_121515249del12 c.1157_1168del12 p.F386_A389delFLIA RefSeq GRCh38/hg38
XM_006717712 chr10:g.121500935_121500946del12 c.1156_1167del12 p.L386_G389delLTLG RefSeq GRCh38/hg38
NM_001144916.1 chr10:g.121500875_121500886del12 c.1156_1167del12 p.V386_D389delVGID RefSeq GRCh38/hg38
XM_006717708.3 chr10:g.121515297_121515308del12 c.1156_1167del12 p.E386_I389delEKEI RefSeq GRCh38/hg38
NM_001144916.2 chr10:g.121500875_121500886del12 c.1156_1167del12 p.V386_D389delVGID RefSeq GRCh38/hg38
NM_001144913 chr10:g.121515240_121515251del12 c.1157_1168del12 p.V386_I389delVFLI RefSeq GRCh38/hg38
NM_000141.5 chr10:g.121515238_121515249del12 c.1157_1168del12 p.F386_A389delFLIA RefSeq GRCh38/hg38
XM_017015923 chr10:g.121503846_121503857del12 c.1156_1167del12 p.P386_A389delPMLA RefSeq GRCh38/hg38
NM_001144915 chr10:g.121503795_121503806del12 c.1158_1169del12 p.E386_R389delEFPR RefSeq GRCh38/hg38
XM_017015922 chr10:g.121503849_121503860del12 c.1156_1167del12 p.T386_L389delTPML RefSeq GRCh38/hg38
XM_017015925.3 chr10:g.121500929_121500940del12 c.1158_1169del12 p.K387_G390delKPLG RefSeq GRCh38/hg38
NM_001144914 chr10:g.121500886_121500897del12 c.1157_1168del12 p.A386_V389delAEAV RefSeq GRCh38/hg38
NM_001144918.2 chr10:g.121500869_121500880del12 c.1157_1168del12 p.I386_D389delIDKD RefSeq GRCh38/hg38
XM_006717711 chr10:g.121503855_121503866del12 c.1156_1167del12 p.A386_P389delADTP RefSeq GRCh38/hg38
NM_001144919 chr10:g.121503799_121503810del12 c.1156_1167del12 p.W386_P389delWEFP RefSeq GRCh38/hg38
NM_001144914.1 chr10:g.121500886_121500897del12 c.1157_1168del12 p.A386_V389delAEAV RefSeq GRCh38/hg38
XM_024447891.2 chr10:g.121500935_121500946del12 c.1156_1167del12 p.L386_G389delLTLG RefSeq GRCh38/hg38
XM_024447887.2 chr10:g.121503852_121503863del12 c.1156_1167del12 p.D386_M389delDTPM RefSeq GRCh38/hg38
XM_024447892.1 chr10:g.121479987_121479998del12 c.1156_1167del12 p.L386_Y389delLEQY RefSeq GRCh38/hg38
NM_001144918 chr10:g.121500869_121500880del12 c.1157_1168del12 p.I386_D389delIDKD RefSeq GRCh38/hg38
NM_000141 chr10:g.121515238_121515249del12 c.1157_1168del12 p.F386_A389delFLIA RefSeq GRCh38/hg38
NM_022970.4 chr10:g.121515240_121515251del12 c.1157_1168del12 p.V386_I389delVFLI RefSeq GRCh38/hg38
NM_001144918.1 chr10:g.121500869_121500880del12 c.1157_1168del12 p.I386_D389delIDKD RefSeq GRCh38/hg38
XM_017015920.3 chr10:g.121515297_121515308del12 c.1156_1167del12 p.E386_I389delEKEI RefSeq GRCh38/hg38
XM_006717710 chr10:g.121515297_121515308del12 c.1156_1167del12 p.E386_I389delEKEI RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121515240_121515251del12 c.1157_1168del12 p.V386_I389delVFLI RefSeq GRCh38/hg38
NM_001144919.2 chr10:g.121503799_121503810del12 c.1156_1167del12 p.W386_P389delWEFP RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121515240_121515251del12 c.1157_1168del12 p.V386_I389delVFLI RefSeq GRCh38/hg38
NM_001320658 chr10:g.121515238_121515249del12 c.1157_1168del12 p.F386_A389delFLIA RefSeq GRCh38/hg38
NM_001144914.1 chr10:g.121500886_121500897del12 c.1157_1168del12 p.A386_V389delAEAV RefSeq GRCh38/hg38
NM_001320658.2 chr10:g.121515238_121515249del12 c.1157_1168del12 p.F386_A389delFLIA RefSeq GRCh38/hg38
XM_024447888.1 chr10:g.121503849_121503860del12 c.1156_1167del12 p.T386_L389delTPML RefSeq GRCh38/hg38
XM_017015920 chr10:g.121515297_121515308del12 c.1156_1167del12 p.E386_I389delEKEI RefSeq GRCh38/hg38
NM_000141.4 chr10:g.121515238_121515249del12 c.1157_1168del12 p.F386_A389delFLIA RefSeq GRCh38/hg38
XM_006717710.4 chr10:g.121515297_121515308del12 c.1156_1167del12 p.E386_I389delEKEI RefSeq GRCh38/hg38
XM_024447889.2 chr10:g.121503846_121503857del12 c.1156_1167del12 p.P386_A389delPMLA RefSeq GRCh38/hg38
XM_024447890.2 chr10:g.121503855_121503866del12 c.1156_1167del12 p.A386_P389delADTP RefSeq GRCh38/hg38
XM_017015925 chr10:g.121500929_121500940del12 c.1158_1169del12 p.K387_G390delKPLG RefSeq GRCh38/hg38
XM_024447889.1 chr10:g.121503846_121503857del12 c.1156_1167del12 p.P386_A389delPMLA RefSeq GRCh38/hg38
NM_023029.2 chr10:g.121503795_121503806del12 c.1158_1169del12 p.E386_R389delEFPR RefSeq GRCh38/hg38
NM_001144916 chr10:g.121500875_121500886del12 c.1156_1167del12 p.V386_D389delVGID RefSeq GRCh38/hg38
NM_001144915.1 chr10:g.121503795_121503806del12 c.1158_1169del12 p.E386_R389delEFPR RefSeq GRCh38/hg38
NM_001320654 chr10:g.121496544_121496555del12 c.1156_1167del12 p.M386_L389delMEYL RefSeq GRCh38/hg38
XM_017015924.3 chr10:g.121500933_121500944del12 c.1156_1167del12 p.T386_K389delTLGK RefSeq GRCh38/hg38
XM_017015921.2 chr10:g.121515295_121515306del12 c.1156_1167del12 p.K386_T389delKEIT RefSeq GRCh38/hg38
XM_017015924.2 chr10:g.121500933_121500944del12 c.1156_1167del12 p.T386_K389delTLGK RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References