FGFR2 L761Tfs*55
Gene Variant Detail

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Gene FGFR2
Variant L761Tfs*55
Impact List frameshift
Protein Effect unknown
Gene Variant Descriptions FGFR2 L761Tfs*55 indicates a shift in the reading frame starting at amino acid 761 and terminating 55 residues downstream causing a premature truncation of the 821 amino acid Fgfr2 protein (UniProt.org). L761Tfs*55 results in increased transformation ability in one of two different cell lines (PMID: 29533785), but has not been fully biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown.
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 L761Tfs*55

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Transcript NM_000141.5
gDNA chr10:g.(121479875_121483718)
cDNA c.(2281_2448)
Protein p.L761Tfs*55
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001320658.1 chr10:g.121483712_121483713insTTTGT c.2280_2281insACAAA p.L761Tfs*55 RefSeq GRCh38/hg38
NM_000141.4 chr10:g.(121479875_121483718) c.(2281_2448) p.L761Tfs*55 RefSeq GRCh38/hg38
NM_000141.5 chr10:g.(121479875_121483718) c.(2281_2448) p.L761Tfs*55 RefSeq GRCh38/hg38
NM_001320658.2 chr10:g.121483712_121483713insTTTGT c.2280_2281insACAAA p.L761Tfs*55 RefSeq GRCh38/hg38
NM_000141 chr10:g.(121479875_121483718) c.(2281_2448) p.L761Tfs*55 RefSeq GRCh38/hg38
NM_001320658 chr10:g.121483713_121483714insACGTT c.2279_2280insAACGT p.L761Tfs*55 RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References