Gene Variant Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Gene FGFR3
Variant A634T
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FGFR3 A634T lies within the protein kinase domain of the Fgfr3 protein (UniProt.org). A634T results in decreased cell proliferation and cell viability compared to wild-type Fgfr3 in one of two different cell lines in culture (PMID: 29533785), but has not been biochemically characterized and therefore, its effect on Fgfr3 protein function is unknown.
Associated Drug Resistance
Category Variants Paths

FGFR3 mutant FGFR3 A634T

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Transcript NM_000142.5
gDNA chr4:g.1806114G>A
cDNA c.1900G>A
Protein p.A634T
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006713873 chr4:g.1806114G>A c.1900G>A p.A634T RefSeq GRCh38/hg38
XM_006713873.1 chr4:g.1806114G>A c.1900G>A p.A634T RefSeq GRCh38/hg38
XM_047449823.1 chr4:g.1806114G>A c.1900G>A p.A634T RefSeq GRCh38/hg38
XM_006713873.2 chr4:g.1806114G>A c.1900G>A p.A634T RefSeq GRCh38/hg38
NM_000142.4 chr4:g.1806114G>A c.1900G>A p.A634T RefSeq GRCh38/hg38
NM_000142 chr4:g.1806114G>A c.1900G>A p.A634T RefSeq GRCh38/hg38
NM_000142.5 chr4:g.1806114G>A c.1900G>A p.A634T RefSeq GRCh38/hg38
XM_047449824.1 chr4:g.1806114G>A c.1900G>A p.A634T RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References