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Gene | FGFR3 |
Variant | A634T |
Impact List | missense |
Protein Effect | unknown |
Gene Variant Descriptions | FGFR3 A634T lies within the protein kinase domain of the Fgfr3 protein (UniProt.org). A634T results in decreased cell proliferation and cell viability compared to wild-type Fgfr3 in one of two different cell lines in culture (PMID: 29533785), but has not been biochemically characterized and therefore, its effect on Fgfr3 protein function is unknown. |
Associated Drug Resistance | |
Category Variants Paths |
FGFR3 mutant FGFR3 A634T |
Transcript | NM_000142.5 |
gDNA | chr4:g.1806114G>A |
cDNA | c.1900G>A |
Protein | p.A634T |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_000142 | chr4:g.1806114G>A | c.1900G>A | p.A634T | RefSeq | GRCh38/hg38 |
XM_006713873 | chr4:g.1806114G>A | c.1900G>A | p.A634T | RefSeq | GRCh38/hg38 |
XM_047449824.1 | chr4:g.1806114G>A | c.1900G>A | p.A634T | RefSeq | GRCh38/hg38 |
XM_047449823.1 | chr4:g.1806114G>A | c.1900G>A | p.A634T | RefSeq | GRCh38/hg38 |
XM_006713873.2 | chr4:g.1806114G>A | c.1900G>A | p.A634T | RefSeq | GRCh38/hg38 |
NM_000142.5 | chr4:g.1806114G>A | c.1900G>A | p.A634T | RefSeq | GRCh38/hg38 |
NM_000142.4 | chr4:g.1806114G>A | c.1900G>A | p.A634T | RefSeq | GRCh38/hg38 |
XM_006713873.1 | chr4:g.1806114G>A | c.1900G>A | p.A634T | RefSeq | GRCh38/hg38 |
Molecular Profile | Protein Effect | Treatment Approaches |
---|---|---|
FGFR3 A634T | unknown |