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Gene FGFR3
Variant V642M
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions FGFR3 V642M lies within the protein kinase domain of the Fgfr3 protein (UniProt.org). V642M results in similar cell proliferation and viability levels as wild-type Fgfr3 in culture (PMID: 29533785), and therefore, is predicted to have no effect on Fgfr3 protein function.
Associated Drug Resistance
Category Variants Paths

FGFR3 mutant FGFR3 V642M

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Transcript NM_000142.5
gDNA chr4:g.1806138G>A
cDNA c.1924G>A
Protein p.V642M
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006713873.1 chr4:g.1806138G>A c.1924G>A p.V642M RefSeq GRCh38/hg38
XM_006713873.2 chr4:g.1806138G>A c.1924G>A p.V642M RefSeq GRCh38/hg38
XM_047449823.1 chr4:g.1806138G>A c.1924G>A p.V642M RefSeq GRCh38/hg38
NM_000142.5 chr4:g.1806138G>A c.1924G>A p.V642M RefSeq GRCh38/hg38
XM_006713873 chr4:g.1806138G>A c.1924G>A p.V642M RefSeq GRCh38/hg38
NM_022965 chr4:g.1806920G>A c.1924G>A p.V642M RefSeq GRCh38/hg38
NM_022965.3 chr4:g.1806920G>A c.1924G>A p.V642M RefSeq GRCh38/hg38
XM_047449824.1 chr4:g.1806138G>A c.1924G>A p.V642M RefSeq GRCh38/hg38
NM_000142.4 chr4:g.1806138G>A c.1924G>A p.V642M RefSeq GRCh38/hg38
NM_022965.4 chr4:g.1806920G>A c.1924G>A p.V642M RefSeq GRCh38/hg38
NM_000142 chr4:g.1806138G>A c.1924G>A p.V642M RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References