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Gene FGFR2
Variant C383R
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions FGFR2 C383R (corresponds to C382R in the canonical isoform) lies within the transmembrane domain of the Fgfr2 protein (UniProt.org). C383R results in Fgfr2 autophosphorylation and transformation in culture (PMID: 9136983), and therefore, is predicted to lead to a gain of Fgfr2 protein function.
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 act mut FGFR2 C383R

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Transcript NM_022970.4
gDNA chr10:g.121515260A>G
cDNA c.1147T>C
Protein p.C383R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001144913.1 chr10:g.121515260A>G c.1147T>C p.C383R RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121515260A>G c.1147T>C p.C383R RefSeq GRCh38/hg38
NM_022970 chr10:g.121515260A>G c.1147T>C p.C383R RefSeq GRCh38/hg38
NM_022970.4 chr10:g.121515260A>G c.1147T>C p.C383R RefSeq GRCh38/hg38
NM_001144913 chr10:g.121515260A>G c.1147T>C p.C383R RefSeq GRCh38/hg38
NM_022970.3 chr10:g.121515260A>G c.1147T>C p.C383R RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries