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Gene PIK3CA
Variant H1047T
Impact List missense
Protein Effect unknown
Gene Variant Descriptions PIK3CA H1047T is a hotspot mutation that lies within the PI3K/PI4K domain of the Pik3ca protein (UniProt.org). H1047T has identified in the scientific literature (PMID: 29636477), but has not been biochemically characterized and therefore, its effect on Pik3ca protein function is unknown (PubMed, Nov 2023).
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA exon21 PIK3CA H1047X PIK3CA H1047T

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Transcript NM_006218.4
gDNA chr3:g.179234296_179234297delCAinsAC
cDNA c.3139_3140delCAinsAC
Protein p.H1047T
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_006218.4 chr3:g.179234296_179234297delCAinsAC c.3139_3140delCAinsAC p.H1047T RefSeq GRCh38/hg38
NM_006218 chr3:g.179234296_179234297delCAinsAC c.3139_3140delCAinsAC p.H1047T RefSeq GRCh38/hg38
XM_006713658.4 chr3:g.179234296_179234297delCAinsAC c.3139_3140delCAinsAC p.H1047T RefSeq GRCh38/hg38
XM_011512894 chr3:g.179234296_179234297delCAinsAC c.3139_3140delCAinsAC p.H1047T RefSeq GRCh38/hg38
XM_006713658 chr3:g.179234296_179234297delCAinsAC c.3139_3140delCAinsAC p.H1047T RefSeq GRCh38/hg38
XM_011512894.2 chr3:g.179234296_179234297delCAinsAC c.3139_3140delCAinsAC p.H1047T RefSeq GRCh38/hg38
NM_006218.3 chr3:g.179234296_179234297delCAinsAC c.3139_3140delCAinsAC p.H1047T RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179234296_179234297delCAinsAC c.3139_3140delCAinsAC p.H1047T RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References