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PIK3CA D538Y - Gene Variant Detail

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Gene PIK3CA
Variant D538Y
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions PIK3CA D538Y lies within the PIK helical domain of the Pik3ca protein (UniProt.org). D538Y results in cell growth levels similar to wild-type Pik3ca in culture (PMID: 29636477), and therefore, is predicted to have no effect on Pik3ca protein function.
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA exon10 PIK3CA D538Y

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Transcript NM_006218.4
gDNA chr3:g.179218282G>T
cDNA c.1612G>T
Protein p.D538Y
Source Database RefSeq
Genome Build GRCh38/hg38

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